1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. ATP

ATP  (Synonyms: Adenosine 5'-triphosphate)

Cat. No.: HY-B2176 Purity: 99.62%
COA Handling Instructions

ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

For research use only. We do not sell to patients.

ATP Chemical Structure

ATP Chemical Structure

CAS No. : 56-65-5

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Customer Review

Based on 32 publication(s) in Google Scholar

Other Forms of ATP:

Top Publications Citing Use of Products

31 Publications Citing Use of MCE ATP

WB

    ATP purchased from MCE. Usage Cited in: Transl Res. 2022.

    LPS/ATP treatment significantly promotes expression of NLRP3 and production of N-GSDMD in HAEC. HAEC are pretreated with LPS (500ng/ml) for 5 h and then stimulated with ATP (5 mM) for 1 h.
    • Biological Activity

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    • Customer Review

    Description

    ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
    ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
    ATP promotes neutrophil chemotaxis in vitro[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
    ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Four-week-old Kunming mice (18-22 g)[4]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
    Result: Protected mice from bacterial infection.
    Molecular Weight

    507.18

    Formula

    C10H16N5O13P3

    CAS No.
    SMILES

    O=P(O)(O)OP(OP(OC[[email protected]]1O[[email protected]@H](N2C3=NC=NC(N)=C3N=C2)[[email protected]](O)[[email protected]@H]1O)(O)=O)(O)=O

    Source

    widespread

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 100 mg/mL (197.17 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9717 mL 9.8584 mL 19.7169 mL
    5 mM 0.3943 mL 1.9717 mL 3.9434 mL
    10 mM 0.1972 mL 0.9858 mL 1.9717 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (197.17 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.62%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    ATP
    Cat. No.:
    HY-B2176
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