1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. ATP

ATP (Synonyms: Adenosine 5'-triphosphate)

Cat. No.: HY-B2176 Purity: >98.0%
Handling Instructions

ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

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ATP Chemical Structure

ATP Chemical Structure

CAS No. : 56-65-5

Size Price Stock Quantity
10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 96 In-stock
Estimated Time of Arrival: December 31
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Based on 5 publication(s) in Google Scholar

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Description

ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

ATP (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4].
ATP stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4].

In Vivo

ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
ATP induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

Animal Model: Four-week-old Kunming mice (18-22 g)[4]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
Result: Protected mice from bacterial infection.
Clinical Trial
Molecular Weight

507.18

Formula

C₁₀H₁₆N₅O₁₃P₃

CAS No.

56-65-5

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]]3COP(O)(OP(OP(O)(O)=O)(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (197.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9717 mL 9.8584 mL 19.7169 mL
5 mM 0.3943 mL 1.9717 mL 3.9434 mL
10 mM 0.1972 mL 0.9858 mL 1.9717 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ATPAdenosine 5'-triphosphateEndogenous MetaboliteenergystoragemetabolismimmunityinflammationNLRP3inflammasomecytokineInhibitorinhibitorinhibit

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