1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. ATP

ATP (Synonyms: Adenosine 5'-triphosphate)

Cat. No.: HY-B2176 Purity: 98.34%
Handling Instructions

ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

For research use only. We do not sell to patients.

ATP Chemical Structure

ATP Chemical Structure

CAS No. : 56-65-5

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Customer Review

Based on 10 publication(s) in Google Scholar

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Description

ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
ATP promotes neutrophil chemotaxis in vitro[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old Kunming mice (18-22 g)[4]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
Result: Protected mice from bacterial infection.
Molecular Weight

507.18

Formula

C₁₀H₁₆N₅O₁₃P₃

CAS No.

56-65-5

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]]3COP(O)(OP(OP(O)(O)=O)(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (197.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9717 mL 9.8584 mL 19.7169 mL
5 mM 0.3943 mL 1.9717 mL 3.9434 mL
10 mM 0.1972 mL 0.9858 mL 1.9717 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.34%

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Keywords:

ATPAdenosine 5'-triphosphateEndogenous MetaboliteenergystoragemetabolismimmunityinflammationNLRP3inflammasomecytokineInhibitorinhibitorinhibit

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