2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. ATP dimagnesium

ATP dimagnesium  (Synonyms: Adenosine 5'-triphosphate dimagnesium)

Cat. No.: HY-B2176B Purity: ≥98.0%
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ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation.

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ATP dimagnesium Chemical Structure

ATP dimagnesium Chemical Structure

CAS No. : 74804-12-9

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Based on 56 publication(s) in Google Scholar

Other Forms of ATP dimagnesium:

ATP dimagnesium Related Antibodies

Top Publications Citing Use of Products

55 Publications Citing Use of MCE ATP dimagnesium

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    ATP dimagnesium purchased from MedChemExpress. Usage Cited in: Transl Res. 2022.

    LPS/ATP treatment significantly promotes expression of NLRP3 and production of N-GSDMD in HAEC. HAEC are pretreated with LPS (500ng/ml) for 5 h and then stimulated with ATP (5 mM) for 1 h.

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    Description

    ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
    ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
    ATP promotes neutrophil chemotaxis in vitro[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ATP dimagnesium Related Antibodies
    In Vivo

    ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
    ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Four-week-old Kunming mice (18-22 g)[4]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
    Result: Protected mice from bacterial infection.
    Molecular Weight

    551.76

    Formula

    C10H12Mg2N5O13P3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=P([O-])([O-])OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1O)([O-])=O)([O-])=O.[Mg+2].[Mg+2]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 250 mg/mL (453.10 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8124 mL 9.0619 mL 18.1238 mL
    5 mM 0.3625 mL 1.8124 mL 3.6248 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.8124 mL 9.0619 mL 18.1238 mL 45.3096 mL
    5 mM 0.3625 mL 1.8124 mL 3.6248 mL 9.0619 mL
    10 mM 0.1812 mL 0.9062 mL 1.8124 mL 4.5310 mL
    15 mM 0.1208 mL 0.6041 mL 1.2083 mL 3.0206 mL
    20 mM 0.0906 mL 0.4531 mL 0.9062 mL 2.2655 mL
    25 mM 0.0725 mL 0.3625 mL 0.7250 mL 1.8124 mL
    30 mM 0.0604 mL 0.3021 mL 0.6041 mL 1.5103 mL
    40 mM 0.0453 mL 0.2265 mL 0.4531 mL 1.1327 mL
    50 mM 0.0362 mL 0.1812 mL 0.3625 mL 0.9062 mL
    60 mM 0.0302 mL 0.1510 mL 0.3021 mL 0.7552 mL
    80 mM 0.0227 mL 0.1133 mL 0.2265 mL 0.5664 mL
    100 mM 0.0181 mL 0.0906 mL 0.1812 mL 0.4531 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    ATP dimagnesium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ATP dimagnesium74804-12-9Adenosine 5'-triphosphate dimagnesiumEndogenous MetaboliteenergystoragemetabolismimmunityinflammationNLRP3inflammasomecytokineInhibitorinhibitorinhibit

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