1. Signaling Pathways
  2. Epigenetics
    PI3K/Akt/mTOR
  3. AMPK

AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

AMPK Isoform Specific Products:

  • NUAK1

  • NUAK2

  • AMPK

  • AMPK α1β1γ1

  • AMPK α2β1γ1

  • AMPK α1β2γ1

  • AMPK α2β2γ1

AMPK Related Products (31):

Cat. No. Product Name Effect Purity
  • HY-15142
    Doxorubicin hydrochloride Inhibitor 99.47%
    Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic for the treatment of multiple cancers. The possible mechanisms by which doxorubicin acts in the cancer cell are intercalation into DNA and disruption of topoisomerase-II-mediated DNA repair.
  • HY-17471A
    Metformin hydrochloride Activator 99.98%
    Metformin (hydrochloride) is an FDA approved first-line drug for the treatment of type 2 diabetes. Metformin decreases hepatic glucose production, mostly through a mild and transient inhibition of the mitochondrial respiratory-chain complex 1.
  • HY-13418
    Dorsomorphin dihydrochloride Inhibitor 99.91%
    Dorsomorphin dihydrochloride (BML-275 dihydrochloride; Compound C dihydrochloride) is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6.
  • HY-13417
    AICAR Activator 99.92%
    AICAR is a cell-permeable AMP-activated protein kinase (AMPK) activator.
  • HY-13418A
    Dorsomorphin Inhibitor 99.65%
    Dorsomorphin (BML-275; Compound C) is a potent and selective AMPK inhibitor, that is competitive with ATP, with Ki=109 nM in the absence of AMP. Dorsomorphin inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6.
  • HY-50662
    A-769662 Activator 98.09%
    A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM.
  • HY-19805
    STO-609 Inhibitor >98.0%
    STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.
  • HY-10249
    GSK-690693 Inhibitor
    GSK-690693 is an ATP-competitive pan-Akt inhibitor with IC50s of 2, 13, 9 nM for Akt1, Akt2 and Akt3, respectively.
  • HY-13417A
    AICAR phosphate Activator >98.0%
    AICAR phosphate is an activator of AMP-activated protein kinase (AMPK).
  • HY-12357
    Bempedoic acid Activator >98.0%
    Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK.
  • HY-16397A
    Phenformin hydrochloride Activator >98.0%
    Phenformin (hydrochloride) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class, can activate AMPK activity.
  • HY-103683
    PF-06409577 Activator 98.56%
    PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.
  • HY-112233
    O-304 Activator 98.63%
    O-304 is a small molecule AMPK activator.
  • HY-15802
    WZ4003 Inhibitor
    WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1 (ARK5)/NUAK2, without significant inhibition on other 139 kinases.
  • HY-14615
    [6]-Gingerol Activator 98.01%
    [6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
  • HY-B1221
    Flufenamic acid Activator 99.92%
    Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels.
  • HY-B0923
    Danthron Activator >98.0%
    Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
  • HY-N6631
    7-Methoxyisoflavone Activator 99.81%
    7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).
  • HY-16708A
    ZLN024 hydrochloride Activator 98.55%
    ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.
  • HY-N2341
    Palmitelaidic Acid Activator >99.0%
    Palmitelaidic acid is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.