1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK

AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

AMPK Isoform Specific Products:

  • NUAK1

  • NUAK2

  • AMPK

  • AMPK α1β1γ1

  • AMPK α2β1γ1

  • AMPK α1β2γ1

  • AMPK α2β2γ1

AMPK Related Products (24):

Cat. No. Product Name Effect Purity
  • HY-13418
    Dorsomorphin dihydrochloride Inhibitor 99.73%
    Dorsomorphin dihydrochloride is a potent and selective AMPK inhibitor, that is competitive with ATP, with Ki of 109±16 nM in the absence of AMP.
  • HY-17471A
    Metformin hydrochloride Activator 99.98%
    Metformin (hydrochloride) is a first-line drug for the treatment of type 2 diabetes and there is increasing evidence of a potential efficacy of this agent as an anti-cancer drug.
  • HY-13417
    AICAR Activator 99.90%
    AICAR is an activator of AMP-activated protein kinase (AMPK), down-regulates the insulin receptor expression in HepG2 cells.
  • HY-50662
    A-769662 Activator 98.09%
    A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, and has little effect on GPPase/FBPase activity.
  • HY-13418A
    Dorsomorphin Inhibitor 98.14%
    Dorsomorphin is a potent and selective AMPK inhibitor, that is competitive with ATP, with Ki=109±16 nM in the absence of AMP.
  • HY-N6631
    7-Methoxyisoflavone Activator 99.81%
    7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).
  • HY-107988
    MK-3903 Activator 98.10%
    MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
  • HY-112108
    Chitosan oligosaccharide COS Activator
    Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.
  • HY-16397A
    Phenformin hydrochloride Activator 98.17%
    Phenformin (hydrochloride) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class, can activate AMPK activity.
  • HY-15802
    WZ4003 Inhibitor
    WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1/NUAK2, without significant inhibition on other 139 kinases.
  • HY-13417A
    AICAR phosphate Activator >98.0%
    AICAR phosphate is an activator of AMP-activated protein kinase (AMPK), down-regulates the insulin receptor expression in HepG2 cells.
  • HY-16708A
    ZLN024 hydrochloride Activator 98.55%
    ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.
  • HY-12357
    ETC-1002 Activator >98.0%
    ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK).
  • HY-12831
    Ampkinone Activator 98.11%
    Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.
  • HY-12334
    HTH-01-015 Inhibitor 98.81%
    HTH-01-015 is a selective NUAK1 inhibitor (IC50 is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM).
  • HY-15840
    YLF-466D Activator 99.16%
    YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.
  • HY-14615
    [6]-Gingerol Activator 98.01%
    [6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
  • HY-103683
    PF-06409577 Activator 98.56%
    PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.
  • HY-B0923
    Danthron Activator >98.0%
    Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
  • HY-N2341
    Palmitelaidic Acid Activator 98.00%
    Palmitelaidic acid is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.