1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK

AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

AMPK Related Products (23):

Cat. No. Product Name Effect Purity
  • HY-13418
    Dorsomorphin dihydrochloride Inhibitor
    Dorsomorphin dihydrochloride is a potent and selective AMPK inhibitor, that is competitive with ATP, with Ki of 109±16 nM in the absence of AMP.
  • HY-13417
    AICAR Activator
    AICAR is an activator of AMP-activated protein kinase (AMPK), down-regulates the insulin receptor expression in HepG2 cells.
  • HY-17471A
    Metformin hydrochloride Activator
    Metformin (hydrochloride) is a first-line drug for the treatment of type 2 diabetes and there is increasing evidence of a potential efficacy of this agent as an anti-cancer drug.
  • HY-50662
    A-769662 Activator
    A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, and has little effect on GPPase/FBPase activity.
  • HY-15802
    WZ4003 Inhibitor
    WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1/NUAK2, without significant inhibition on other 139 kinases.
  • HY-N2341
    Palmitelaidic Acid
    Palmitelaidic acid is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
  • HY-14615
    [6]-Gingerol Activator
    [6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
  • HY-16397A
    Phenformin hydrochloride Activator
    Phenformin (hydrochloride) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class, can activate AMPK activity.
  • HY-12831
    Ampkinone Activator
    Ampkinone is a small molecule activator of AMPK; stimulate functional activation of AMPK via the phosphorylation at Thr172 in cultured L6 muscle cells with an EC50 value of 4.3 μM, enhancing glucose uptake by 3.2-fold.
  • HY-12357
    ETC-1002 Activator
    ETC-1002 (ESP-55016) is an activator of hepatic AMP-activated protein kinase (AMPK); also an inhibitor of hepatic ATP-citrate lyase (ACL) with an IC50 of 29 μM.
  • HY-12334
    HTH-01-015 Inhibitor
    HTH-01-015 is a potent and selective inhibitor of NUAK1 with IC50 of 100 nM, does not significantly inhibit NUAK2 (IC50 of >10 μM).
  • HY-16708A
    ZLN024 hydrochloride Activator
    ZLN024 Hcl is a novel AMPK allosteric activator; activated α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 uM.
  • HY-15840
    YLF-466D Inhibitor
    YLF-466D is an allosteric AMPK activator.
  • HY-14537
    Latrepirdine dihydrochloride Activator
    Latrepirdine (dihydrochloride) is a potent activator of AMPK, also an anti-histamine, promote the removal of α-synuclein protein aggregates.
  • HY-B0923
    Danthron Activator
    Danthron is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes.
  • HY-N0109
    Salidroside Activator
    Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata.
  • HY-14771
    Imeglimin Activator
    Imeglimin(EMD-387008) is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins; It has been shown to act on the liver, muscle and pancreatic β-cells to uniquely target the key defects of type 2 diabetes.
  • HY-13418A
    Dorsomorphin Inhibitor
    Dorsomorphin(Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), B
  • HY-13417A
    AICAR phosphate Activator
    AICAR phosphate (Acadesine), is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
  • HY-14771A
    Imeglimin hydrochloride Activator
    Imeglimin(EMD 387008) is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. It has been shown to act on the liver, muscle and pancreatic β-cells to uniquely target the key defects of type 2 diabetes.