1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK

AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

AMPK Related Products (25):

Cat. No. Product Name Effect Purity
  • HY-13418
    Dorsomorphin dihydrochloride Inhibitor 99.73%
    Dorsomorphin dihydrochloride is a potent and selective AMPK inhibitor, that is competitive with ATP, with Ki of 109±16 nM in the absence of AMP.
  • HY-17471A
    Metformin hydrochloride Activator 99.08%
    Metformin (hydrochloride) is a first-line drug for the treatment of type 2 diabetes and there is increasing evidence of a potential efficacy of this agent as an anti-cancer drug.
  • HY-13417
    AICAR Activator 99.84%
    AICAR is an activator of AMP-activated protein kinase (AMPK), down-regulates the insulin receptor expression in HepG2 cells.
  • HY-50662
    A-769662 Activator 98.80%
    A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, and has little effect on GPPase/FBPase activity.
  • HY-16397A
    Phenformin hydrochloride Activator 98.17%
    Phenformin (hydrochloride) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class, can activate AMPK activity.
  • HY-103683
    PF-06409577 Activator
    PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.
  • HY-P0136
    SAMS
    SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).
  • HY-15802
    WZ4003 Inhibitor
    WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1/NUAK2, without significant inhibition on other 139 kinases.
  • HY-12357
    ETC-1002 Activator >98.0%
    ETC-1002 (ESP-55016) is an activator of hepatic AMP-activated protein kinase (AMPK); also an inhibitor of hepatic ATP-citrate lyase (ACL) with an IC50 of 29 μM.
  • HY-12831
    Ampkinone Activator 98.11%
    Ampkinone is a small molecule activator of AMPK; stimulate functional activation of AMPK via the phosphorylation at Thr172 in cultured L6 muscle cells with an EC50 value of 4.3 μM, enhancing glucose uptake by 3.2-fold.
  • HY-16708A
    ZLN024 hydrochloride Activator 98.55%
    ZLN024 Hcl is a novel AMPK allosteric activator; activated α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 uM.
  • HY-12334
    HTH-01-015 Inhibitor 99.65%
    HTH-01-015 is a potent and selective inhibitor of NUAK1 with IC50 of 100 nM, does not significantly inhibit NUAK2 (IC50 of >10 μM).
  • HY-14537
    Latrepirdine dihydrochloride Activator 99.75%
    Latrepirdine (dihydrochloride) is a potent activator of AMPK, also an anti-histamine, promote the removal of α-synuclein protein aggregates.
  • HY-N0109
    Salidroside Activator 98.46%
    Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata.
  • HY-15840
    YLF-466D Activator 99.16%
    YLF-466D is an allosteric AMPK activator.
  • HY-13417A
    AICAR phosphate Activator >98.0%
    AICAR phosphate is an activator of AMP-activated protein kinase (AMPK), down-regulates the insulin receptor expression in HepG2 cells.
  • HY-B0923
    Danthron Activator >98.0%
    Danthron is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes.
  • HY-14615
    [6]-Gingerol Activator 98.01%
    [6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
  • HY-14771A
    Imeglimin hydrochloride Activator >98.0%
    Imeglimin(EMD 387008) is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. It has been shown to act on the liver, muscle and pancreatic β-cells to uniquely target the key defects of type 2 diabetes.
  • HY-N2341
    Palmitelaidic Acid 98.00%
    Palmitelaidic acid is the trans isomer of palmitoleic acid.