2. Metabolic Enzyme/Protease Epigenetics PI3K/Akt/mTOR
  3. Fructose-1,6-bisphosphate aldolase AMPK
  4. Aldometanib

Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis.

For research use only. We do not sell to patients.

CAS No. : 2904601-67-6

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Based on 9 publication(s) in Google Scholar

Aldometanib Related Antibodies

Top Publications Citing Use of Products

    Aldometanib purchased from MedChemExpress. Usage Cited in: Cell Res. 2025 Dec;35(12):934-953.  [Abstract]

    Aldometanib treatment enables HCC-bearing mice to live to a similar age to normal mice. Wild-type C57BL/6 mice (4 weeks old) were intraperitoneally injected with DEN once a week for 2 weeks, followed by feeding with HFD 2 weeks later. The mice were then administered Aldometanib at 100 mg/L in drinking water starting at 12 weeks of age. The lifespans of HCC-bearing mice are shown as Kaplan–Meier curves.

    Aldometanib purchased from MedChemExpress. Usage Cited in: Cell Res. 2025 Dec;35(12):934-953.  [Abstract]

    Aldometanib inhibits the growth of HCC in DEN-HFD mice. Mice were induced to develop HCC using DEN and HFD. Aldometanib at 50 mg/L, 100 mg/L, or 150 mg/L was administered in drinking water starting at week 12 of age, and tissue samples were collected at week 48. The numbers of tumors in each size/diameter category for each dosage of aldometanib are shown: 0–1 mm, 1–3 mm, 3–5 mm, 5–7 mm, 7–9 mm, and > 9 mm tumors.

    Aldometanib purchased from MedChemExpress. Usage Cited in: Cell Res. 2025 Dec;35(12):934-953.  [Abstract]

    Aldometanib (50-150 mg/L, drinking water) suppresses AFP levels in DEN-HFD mice. HCC tissues from aldometanib-treated and untreated DEN-HFD mice,were subjected to immunohistochemistry (IHC) staining for AFP.

    Aldometanib purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Jul;44(13):3669-3696.  [Abstract]

    Luciferase-based assay for ATP measurement. Graph shows values of relative light units (RLU) normalized to total protein levels for each condition. Conditions are under resting or glucose stimulating conditions with the addition of DMSO (vehicle), Aldometanib (200 nM), pyruvate (20 mM) or rotenone (50 nM)

    Aldometanib purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Jul;44(13):3669-3696.  [Abstract]

    Immunostaining for G3BP1 (green), eIF3b (red) and smRNA FISH for Ins1/2 (gray) under resting or stimulating glucose conditions the addition of DMSO (vehicle), Aldometanib (200 nM) or pyruvate (20 mM). Nuclei are stained with DAPI (blue).

    Aldometanib purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Jul;44(13):3669-3696.  [Abstract]

    Western blot p-AMPKαThr172, p-mTORSer2448 and gamma-tubulin across varying conditions: resting and stimulating glucose concentrations, with and without aldometanib treatment as shown in the figure.

    Aldometanib purchased from MedChemExpress. Usage Cited in: Cell Res. 2024 Oct;34(10):683-706.  [Abstract]

    Inhibition of glutaminolysis blocks the LPS-induced death in mice. WT mice were orally gavaged with 12.5 mg/kg BPTES, intraperitoneally injected with 10 mg/kg compound 968, or orally gavaged with 2 mg/kg Aldometanib. After 0.5 h of injection, mice were intraperitoneally injected with 10 mg/kg LPS, followed by determining their survival. Survival curves are displayed as Kaplan–Meier curves.

    View All AMPK Isoform Specific Products:

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    NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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    Description

    Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis[1].

    In Vitro

    Aldometanib (0-1000 nM; 2 h) activates AMPK by preventing aldolase from binding to FBP to engender a pseudo-starvation signal[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Aldometanib Related Antibodies

    Western Blot Analysis[1]

    Cell Line: Mouse primary hepatocytes, MEFs cells
    Concentration: 0-1000 nM
    Incubation Time: 2 h
    Result: Activated AMPK in mouse embryonic fibroblasts (MEFs) and mouse primary hepatocytes cells.

    Immunofluorescence[1]

    Cell Line: MEFs cells
    Concentration: 5 nM
    Incubation Time: 2 h
    Result: Inhibited TRPVs and induces AXIN lysosomal translocation.
    In Vivo

    Aldometanib (oral; 0-10 mpk) reduces blood glucose in lean mice[1].
    Aldometanib (oral; 2-10 mpk; twice daily; for a week) reduces blood glucose and alleviates fatty liver in obese hyperglycaemic mice[1].
    Aldometanib alleviates fatty liver and nonalcoholic steatohepatitis[1].
    Aldometanib (oral; 2mpk; twice-daily; for a month) alleviates liver fibrosis in NASH mice[1].
    Aldometanib (oral; 0-50 μM; 0-50 days) extends lifespan in C. elegans via the lysosomal pathway[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Lean mice[1]
    Dosage: 0-10 mpk
    Administration: Oral
    Result: Decreased fasting blood glucose and improved glucose tolerance, promoted muscular TBC1D1 phosphorylation and glucose uptake.
    Animal Model: Obese hyperglycaemic mice[1]
    Dosage: 2-10 mpk
    Administration: Oral, twice daily, for a week
    Result: Decreased blood glucose, lowered blood glucose in a muscular AMPK-dependent manner reduced hepatic TAG, improved insulin sensitivity, increased glucose disposal rates, inhibited TAG synthesis in liver and primary hepatocytes, decreased fat mass.
    Animal Model: NASH mice[1]
    Dosage: 2 mpk
    Administration: Oral, twice-daily, for a month
    Result: Decreased histological scores used to describe the features of NASH, reduced apoptosis rate of hepatic cells, inhibited inflammatory responses in the liver of NASH mice and improved glucose tolerance of NASH mice.
    Animal Model: C. elegans[1]
    Dosage: 0-50 μM
    Administration: Oral, 0-50 days
    Result: Promoted oxidative stress resistance and mitochondrial functions in C. elegans.
    Animal Model: C57BL/6 mice[1]
    Dosage: 100 μg/mL
    Administration: Oral
    Result: Extended lifespan, elevated NAD＋ levels and mitochondrial oxidative respiration, rejuvenated muscle function in aged mice.
    Molecular Weight

    593.45

    Formula

    C27H43Cl2IN2
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    CCCCCCCCCCCCCCCCN1C=C[N+](CC2=C(Cl)C=CC=C2Cl)=C1C.[I-]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (168.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6851 mL 8.4253 mL 16.8506 mL
    5 mM 0.3370 mL 1.6851 mL 3.3701 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (4.21 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    g

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.6851 mL 8.4253 mL 16.8506 mL 42.1265 mL
    5 mM 0.3370 mL 1.6851 mL 3.3701 mL 8.4253 mL
    10 mM 0.1685 mL 0.8425 mL 1.6851 mL 4.2127 mL
    15 mM 0.1123 mL 0.5617 mL 1.1234 mL 2.8084 mL
    20 mM 0.0843 mL 0.4213 mL 0.8425 mL 2.1063 mL
    25 mM 0.0674 mL 0.3370 mL 0.6740 mL 1.6851 mL
    30 mM 0.0562 mL 0.2808 mL 0.5617 mL 1.4042 mL
    40 mM 0.0421 mL 0.2106 mL 0.4213 mL 1.0532 mL
    50 mM 0.0337 mL 0.1685 mL 0.3370 mL 0.8425 mL
    60 mM 0.0281 mL 0.1404 mL 0.2808 mL 0.7021 mL
    80 mM 0.0211 mL 0.1053 mL 0.2106 mL 0.5266 mL
    100 mM 0.0169 mL 0.0843 mL 0.1685 mL 0.4213 mL
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    Aldometanib Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Aldometanib2904601-67-6LXY-05-029Fructose-1,6-bisphosphate aldolaseAMPKFructose-1,6-bisphosphate aldolase (FBA)AMP-activated protein kinaseoraladenosine monophosphate-activated protein kinase (AMPK)blood glucosemetabolicInhibitorinhibitorinhibit

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