1. Epigenetics
    PI3K/Akt/mTOR
    Cell Cycle/DNA Damage
  2. AMPK
    HDAC
  3. Marein

Marein 

Cat. No.: HY-N7676
Handling Instructions

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects.

For research use only. We do not sell to patients.

Marein Chemical Structure

Marein Chemical Structure

CAS No. : 535-96-6

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Description

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects[1][2][3].

IC50 & Target

IC50: 100 µM (HDAC)[3]

Molecular Weight

450.39

Formula

C₂₁H₂₂O₁₁

CAS No.

535-96-6

SMILES

O=C(C1=CC=C(O[[email protected]]2[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]@H](CO)O2)O)O)O)C(O)=C1O)/C=C/C3=CC=C(O)C(O)=C3

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MareinAMPKHDACAMP-activated protein kinaseHistone deacetylasesCaMKKGLUT1IRSAktGSK-3βFoxO1antioxidativeantihypertensiveantihyperlipidemicantidiabeticneuroprotectiveglycosideInhibitorinhibitorinhibit

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Marein
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