1. GPCR/G Protein
  2. CaSR

CaSR

CaSR (calcium-sensing receptor) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. In theparathyroid gland, the calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone (PTH). The release of PTH is inhibited in response to elevations in plasma calcium concentrations and activation of the calcium receptor. Increased calcium binding on the extracellular side gives a conformational change in the receptor, which, on the intracellular side, initiates the phospholipase C pathway, presumably through a Gqα type of G protein, which ultimately increases intracellular concentration of calcium, which inhibits vesicle fusion and exocytosis of parathyroid hormone. It also inhibits the cAMP dependent pathway.

CaSR Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-10007
    NPS-2143 Inhibitor
    NPS-2143 is a novel potent and selective antagonist of Ca2+ receptor with IC50 of 43 nM.
  • HY-70037
    Cinacalcet Agonist
    Cinacalcet is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
  • HY-70037A
    Cinacalcet hydrochloride Agonist
    Cinacalcet hydrochloride is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
  • HY-10171
    NPS-2143 hydrochloride Antagonist
    NPS-2143(SB 262470A ) is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2(addition) concentrations and parathyroid hormone secretion, respectively.
  • HY-50713
    Calcium-Sensing Receptor Antagonists I Antagonist
    Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors.
  • HY-17397
    Strontium Ranelate Activator
    Strontium ranelate(S12911) stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.