Etelcalcetide hydrochloride
Based on 2 publication(s) in Google Scholar
Etelcalcetide hydrochloride (AMG 416 hydrochloride; KAI-4169 hydrochloride) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease.
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- Purity : 99.80%
- CAS No.: 1334237-71-6
- 화학식: C38H73N21O10S2.17/2HCl
- 분자량:1353.33
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보관:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Etelcalcetide hydrochloride
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Biological Activity
제품 설명
In Vitro
Etelcalcetide hydrochloride (0-100 µmol/L, 2 h) dose-dependently reduces parathyroid hormone (PTH) levels in human parathyroid cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL7/6J male mice
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Dosage:2.5 µg/h and 20 µg/h
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Administration:infusion, 3 days
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Result:Significantly reduced plasma PTH concentrations and unaltered Cldn14 expression with 2.5 µg/h, but decreased the renal expression of Cyp24a1 with 20 µg/h [1]
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1334237-71-6
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Appearance Solid
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분자량 1353.33
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화학식 C38H73N21O10S2.17/2HCl
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Color White to off-white
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Synonyms
Velcalcetide hydrochloride; AMG 416 hydrochloride; KAI-4169 hydrochloride
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Sequence
Ac-dCys(disulfide bridge:Cys)-d(Ala-Arg-Arg-Arg-Ala-Arg)-NH2
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Sequence Shortening
Ac-dCys(disulfide bridge:Cys)-d(ARRRAR)-NH2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Commun Biol
Absence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges. [Abstract]2024 Apr 25;7(1):501. PMID: 38664468 -
J Clin Endocrinol Metab
Heterogenous Origins of Calcium Homeostasis Disorders Arising from Five Heterozygous Calcium-Sensing Receptor Variants. [Abstract]2025 Jun 17;110(7):1865-1880. PMID: 39413244
용액&용해도
In Vitro:
H2O : 100 mg/mL (73.89 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (73.89 mM); Clear solution; Need ultrasonic
순도&문서
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Differential parathyroid and kidney Ca2+-sensing receptor activation in autosomal dominant hypocalcemia 1 [Content Brief]
[2]. Fujioka A, et al. Effect of etelcalcetide on parathyroid hormone secretion by primary hyperparathyroidism patient-derived primary parathyroid cells[J]. J Bone Miner Metab. 2021 May;39(3):396-403. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.7389 mL | 3.6946 mL | 7.3892 mL | 18.4730 mL |
| 5 mM | 0.1478 mL | 0.7389 mL | 1.4778 mL | 3.6946 mL | |
| 10 mM | 0.0739 mL | 0.3695 mL | 0.7389 mL | 1.8473 mL | |
| 15 mM | 0.0493 mL | 0.2463 mL | 0.4926 mL | 1.2315 mL | |
| 20 mM | 0.0369 mL | 0.1847 mL | 0.3695 mL | 0.9236 mL | |
| 25 mM | 0.0296 mL | 0.1478 mL | 0.2956 mL | 0.7389 mL | |
| 30 mM | 0.0246 mL | 0.1232 mL | 0.2463 mL | 0.6158 mL | |
| 40 mM | 0.0185 mL | 0.0924 mL | 0.1847 mL | 0.4618 mL | |
| 50 mM | 0.0148 mL | 0.0739 mL | 0.1478 mL | 0.3695 mL | |
| 60 mM | 0.0123 mL | 0.0616 mL | 0.1232 mL | 0.3079 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Etelcalcetide hydrochloride Related Classifications
HY-P1955A Related Classifications
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