1. GPCR/G Protein
  2. CaSR
  3. Etelcalcetide hydrochloride

Etelcalcetide hydrochloride  (Synonyms: AMG 416 hydrochloride; KAI-4169 hydrochloride)

Cat. No.: HY-P1955A Purity: 99.61%
COA Handling Instructions

Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Etelcalcetide hydrochloride Chemical Structure

Etelcalcetide hydrochloride Chemical Structure

CAS No. : 1334237-71-6

Size Price Stock Quantity
1 mg USD 40 In-stock
5 mg USD 85 In-stock
10 mg USD 130 In-stock
25 mg USD 250 In-stock
50 mg USD 420 In-stock
100 mg USD 690 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Etelcalcetide hydrochloride:

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  • Biological Activity

  • Purity & Documentation

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Description

Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis[1].

Clinical Trial
Molecular Weight

1353.33

Formula

C38H73N21O10S2.17/2HCl

CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

C1' . Ac-{d-Cys1}-{d-Ala}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Ala}-{d-Arg}-NH2 (Disulfide bridge: Cys1'-Cys1)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (73.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7389 mL 3.6946 mL 7.3892 mL
5 mM 0.1478 mL 0.7389 mL 1.4778 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (73.89 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.61%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7389 mL 3.6946 mL 7.3892 mL 18.4730 mL
5 mM 0.1478 mL 0.7389 mL 1.4778 mL 3.6946 mL
10 mM 0.0739 mL 0.3695 mL 0.7389 mL 1.8473 mL
15 mM 0.0493 mL 0.2463 mL 0.4926 mL 1.2315 mL
20 mM 0.0369 mL 0.1847 mL 0.3695 mL 0.9236 mL
25 mM 0.0296 mL 0.1478 mL 0.2956 mL 0.7389 mL
30 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.6158 mL
40 mM 0.0185 mL 0.0924 mL 0.1847 mL 0.4618 mL
50 mM 0.0148 mL 0.0739 mL 0.1478 mL 0.3695 mL
60 mM 0.0123 mL 0.0616 mL 0.1232 mL 0.3079 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Etelcalcetide hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Etelcalcetide hydrochloride
Cat. No.:
HY-P1955A
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