1. Recombinant Proteins
  2. Fc Receptors
  3. Immunoglobulin Fc Region

Immunoglobulin Fc Region

FCRL molecules belong to the immunoglobulin super family (IgSF) with a potential activating and inhibitory roles. The FCRL genes encode two intracellular receptors (FCRL A and B) and six transmembrane glycoproteins type I (FCRL1-6). FCRL1-6 are all type 1 transmembrane glycoproteins that contain immunoglobulin-like domains in their extracellular regions. They consist of three to nine immunoglobulin (Ig)-like domains in the extracellular region and immunoreceptor tyrosine-based activation (ITAM)/inhibition (ITIM) motifs in their cytoplasmic domain. Unlike FcRs, which are typically either activatory or inhibitory, three of the FCRLs (FCRL2, FCRL3, and FCRL5) contain both activatory and inhibitory sequences, suggesting that they might be capable of dual-modulation. FCRL1-5 are dominantly expressed in different stages of B-cells development. But, FCRL6 is preferentially expressed in different subsets of T-cells and NK cells. FCRL1-5 could regulate different features of B-cell evolution such as development, differentiation, activation, antibody secretion and isotype switching.

Cat. No. Product Name / Synonyms Species Source
  • HY-P70796
    IgG1 Protein, Human (D239E, L241M, HEK293)

    Ig gamma-1 chain C region; IGHG1

    Human HEK293
    The IgG1 protein is the constant region of the immunoglobulin heavy chain and serves as a receptor during the recognition phase of humoral immunity. It triggers clonal expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. IgG1 Protein, Human (D239E, L241M, HEK293) is the recombinant human-derived IgG1 protein, expressed by HEK293 , with tag free. The total length of IgG1 Protein, Human (D239E, L241M, HEK293) is 227 a.a., with molecular weight of ~33 kDa.
  • HY-P73143
    IgG1 Protein, Human (C103S, HEK293)

    Immunoglobulin heavy constant gamma 1; IGHG1

    Human HEK293
    The IgG1 protein is the constant region of the immunoglobulin heavy chain and serves as a receptor during the recognition phase of humoral immunity. It triggers clonal expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. IgG1 Protein, Human (C103S, HEK293) is the recombinant human-derived IgG1 protein, expressed by HEK293 , with tag free. The total length of IgG1 Protein, Human (C103S, HEK293) is 232 a.a., with molecular weight of approximately 34 kDa.
  • HY-P72603
    IgG2A Fc Protein, Mouse (HEK293)

    Ig gamma-2 chain C region; IgG2A Fc

    Mouse HEK293
    Ig gamma-2A chain C region (Immunoglobulin heavy chain gamma polypeptide) is one of the five types of mammalian immunoglobulin heavy chain: γ, δ, α, μ and ε. Heavy chain γ defines the classes of immunoglobulins IgG. IgG2A Fc Protein, Mouse (HEK293) is the recombinant mouse-derived IgG2A Fc protein, expressed by HEK293 , with tag free. The total length of IgG2A Fc Protein, Mouse (HEK293) is 232 a.a., with molecular weight of 30-35 kDa.
  • HY-P72379
    IgG1 Protein, Human (Biotinylated, HEK293, Avi)

    Ig gamma-1 chain C region; IGHG1

    Human HEK293
    The IgG1 protein is the constant region of the immunoglobulin heavy chain and serves as a receptor during the recognition phase of humoral immunity. It triggers clonal expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. IgG1 Protein, Human (Biotinylated, HEK293, Avi) is the recombinant human-derived IgG1 protein, expressed by HEK293 , with C-Avi labeled tag. The total length of IgG1 Protein, Human (Biotinylated, HEK293, Avi) is 227 a.a., with molecular weight of ~33 kDa.
  • HY-P73903
    IgG1 Protein, Human (CHO)

    Immunoglobulin heavy constant gamma 1; IGHG1

    Human CHO
    The IgG1 protein is the constant region of the immunoglobulin heavy chain and serves as a receptor during the recognition phase of humoral immunity. It triggers clonal expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. IgG1 Protein, Human (CHO) is the recombinant human-derived IgG1 protein, expressed by CHO , with tag free. The total length of IgG1 Protein, Human (CHO) is 232 a.a., with molecular weight of ~34 kDa.
  • HY-P700736
    IgE Protein, Human (HEK293, His-Avi)

    Ig epsilon chain C region; IgE

    Human HEK293
    IgE protein is an important immunoglobulin component that participates in the recognition and effector phases of humoral immunity. As a membrane-bound receptor on B lymphocytes, IgE triggers clonal expansion upon antigen binding, leading to plasma cell differentiation. IgE Protein, Human (HEK293, His-Avi) is the recombinant human-derived IgE protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IgE Protein, Human (HEK293, His-Avi) is 220 a.a., with molecular weight of 30-40 kDa.
  • HY-P70771
    IgG4 Fc Protein, Human (HEK293)

    Ig gamma-4 chain C region,IgG4 Fc

    Human HEK293
    The IgG4 Fc is the constant region of the immunoglobulin heavy chain, which forms the backbone of antibodies crucial in humoral immunity. B lymphocytes produce glycoprotein antibodies that initiate clonal expansion upon antigen binding. IgG4 Fc Protein, Human (HEK293) is the recombinant human-derived IgG4 Fc protein, expressed by HEK293 , with tag free. The total length of IgG4 Fc Protein, Human (HEK293) is 228 a.a., with molecular weight of ~32.0 kDa.
  • HY-P73901
    IgG1 Protein, Mouse (HEK293, C102S)

    Immunoglobulin heavy constant gamma 1; IGHG1

    Mouse HEK293
    IgG1 Protein is the most abundant Immunoglobulin G (IgG) subclass in human sera and is important for mediating antibody responses against viral pathogens. IgG1 enables antigen binding activity and immunoglobulin receptor binding activity. It acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity, phagocytosis, and positive regulation of immune response. IgG1 Protein, Mouse (HEK293, C102S) is the recombinant mouse-derived IgG1 protein, expressed by HEK293 , with tag free. The total length of IgG1 Protein, Mouse (HEK293, C102S) is 227 a.a., with molecular weight of ~32 kDa.
  • HY-P70763
    IgG1 Protein, Mouse (HEK293)

    Ig gamma-1 chain C region; IGHG1

    Mouse HEK293
    The immunoglobulin heavy chain constant region is the heavy chain constant region of immunoglobulin. Sequence differences between immunoglobulin heavy chains leads to the various isotypes with different characteristic. IgG1 Protein, Mouse (HEK293) is the recombinant mouse-derived IgG1 protein, expressed by HEK293 , with tag free. The total length of IgG1 Protein, Mouse (HEK293) is 226 a.a., with molecular weight of ~30.0 kDa.
  • HY-P70278
    Ig Lambda Constant 2 Protein, Human (HEK293, His)

    rHuImmunoglobulin lambda constant 2, His; Ig lambda constant 2; Immunoglobulin Lambda Constant 2; Ig Lambda C Domain; IGLC; IGLC2; immunoglobulin lambda constant 2 (Kern-Oz- marker); MGC20392; MGC45681

    Human HEK293
    The Ig Lambda Constant 2 protein is part of the constant region of the immunoglobulin light chain. It acts as a receptor during the recognition phase of humoral immunity, triggering B lymphocyte expansion and differentiation into plasma cells. Ig Lambda Constant 2 Protein, Human (HEK293, His) is the recombinant human-derived Ig Lambda Constant 2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ig Lambda Constant 2 Protein, Human (HEK293, His) is 106 a.a., with molecular weight of ~16.0 kDa.
  • HY-P72604
    IgG2A Fc Protein, Rat (HEK293)

    Ig gamma-2 chain C region; IgG2A Fc

    Rat HEK293
    Ig gamma-2A chain C region (IgG2a) is one of the IgG antibodies subclasses and responses to an antigen. IgG2a plays a crucial role in the adaptive immune response. IgG2A Fc Protein, Rat (HEK293) is the recombinant rat-derived IgG2A Fc protein, expressed by HEK293 , with tag free. The total length of IgG2A Fc Protein, Rat (HEK293) is 225 a.a., with molecular weight of 30-35 kDa.
  • HY-P72609
    Ig kappa Protein, Human (HEK293, His)

    Ig kappa chain C region; IGKC; Immunoglobulin Kappa

    Human HEK293
    Ig kappa protein is the constant region of an immunoglobulin light chain and is part of a membrane-bound or secreted glycoprotein produced by B lymphocytes. Ig kappa Protein, Human (HEK293, His) is the recombinant human-derived Ig kappa protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ig kappa Protein, Human (HEK293, His) is 106 a.a., with molecular weight of ~14 kDa.
  • HY-P73904
    IgG Protein, Rabbit (T185A, N284S, HEK293)

    Ig gamma chain C region; IgG

    Rabbit HEK293
    IgG protein, exhibits the D12 allotypic marker with the 104-Thr sequence and the E14 marker with 185-Thr. IgG Protein, Rabbit (T185A, N284S, HEK293) is the recombinant Rabbit-derived IgG protein, expressed by HEK293 , with tag free. The total length of IgG Protein, Rabbit (T185A, N284S, HEK293) is 223 a.a., with molecular weight of 30-38 kDa.
  • HY-P73907
    IgE Protein, Human (HEK293, His)

    Immunoglobulin heavy constant epsilon; IGHE; IgE

    Human HEK293
    IgE protein is an important immunoglobulin component that participates in the recognition and effector phases of humoral immunity. As a membrane-bound receptor on B lymphocytes, IgE triggers clonal expansion upon antigen binding, leading to plasma cell differentiation. IgE Protein, Human (HEK293, His) is the recombinant human-derived IgE protein, expressed by HEK293 , with C-His labeled tag. The total length of IgE Protein, Human (HEK293, His) is 220 a.a., with molecular weight of ~26-35 kDa.
  • HY-P74842
    IgJ Protein, Human (His)

    Immunoglobulin J chain; JCHAIN; IGCJ; IGJ

    Human E. coli
    The IgJ protein links IgM or IgA monomers, nucleating IgM pentamers and inducing IgA dimer or polymer formation. It also binds these immunoglobulins to the secretory component. As part of the sIgA complex, IgJ integrates with IgA monomers, the J chain, and the secretory component (PIGR proteolytic product). IgJ Protein, Human (His) is the recombinant human-derived IgJ protein, expressed by E. coli , with C-His labeled tag. The total length of IgJ Protein, Human (His) is 137 a.a., with molecular weight of ~26 kDa.
  • HY-P77694
    IgE Protein, Cynomolgus (HEK293, His-Avi)

    Ig epsilon chain C region; IgE

    Cynomolgus HEK293
    IgE protein is an important immunoglobulin component that participates in the recognition and effector phases of humoral immunity. As a membrane-bound receptor on B lymphocytes, IgE triggers clonal expansion upon antigen binding, leading to plasma cell differentiation. IgE Protein, Cynomolgus (HEK293, His-Avi) is the recombinant cynomolgus-derived IgE protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IgE Protein, Cynomolgus (HEK293, His-Avi) is 222 a.a., with molecular weight of 35-40 kDa.
  • HY-P77695
    IgE Protein, Mouse (HEK293, His)

    Ig epsilon chain C region; IgE

    Mouse HEK293
    IgE is an important component of the immunoglobulin chain that coordinates humoral immunity. As a receptor, membrane-bound IgE initiates clonal expansion and B cell differentiation. IgE Protein, Mouse (HEK293, His) is the recombinant mouse-derived IgE protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of IgE Protein, Mouse (HEK293, His) is 331 a.a., with molecular weight (glycosylation form) of 50-60 kDa.
  • HY-P77696
    IgE Protein, Mouse (HEK293, His-Avi)

    Ig epsilon chain C region; IgE

    Mouse HEK293
    IgE is an important component of the immunoglobulin chain that coordinates humoral immunity. As a receptor, membrane-bound IgE initiates clonal expansion and B cell differentiation. IgE Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived IgE protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IgE Protein, Mouse (HEK293, His-Avi) is 224 a.a., with molecular weight of 30-40 kDa.
  • HY-P70796A
    IgG1 Protein, Human (D239E, L241E, HEK293)

    Ig gamma-1 chain C region; IGHG1

    Human HEK293
    The IgG1 protein is the constant region of the immunoglobulin heavy chain and serves as a receptor during the recognition phase of humoral immunity. It triggers clonal expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. IgG1 Protein, Human (D239E, L241E, HEK293) is the recombinant human-derived IgG1 protein, expressed by HEK293 , with tag free. The total length of IgG1 Protein, Human (D239E, L241E, HEK293) is 227 a.a., with molecular weight of 32-34 kDa.
  • HY-P77526
    IgG1 Protein, Human (Biotinylated, C103S, HEK293)

    Immunoglobulin heavy constant gamma 1; IGHG1

    Human HEK293
    The IgG1 protein is the constant region of the immunoglobulin heavy chain and serves as a receptor during the recognition phase of humoral immunity. It triggers clonal expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. IgG1 Protein, Human (Biotinylated, C103S, HEK293) is the recombinant human-derived IgG1 protein, expressed by HEK293 , with tag free. The total length of IgG1 Protein, Human (Biotinylated, C103S, HEK293) is 232 a.a., with molecular weight of ~26.1 KDa.
Cat. No. Product Name Effect Purity