1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Stimulatory immune checkpoint molecules

Stimulatory immune checkpoint molecules

As opposed to inhibitory pathways that attenuate the immune system, co-stimulatory molecules augment immunological responses against malignant cells. Malignant cells often inhibit co-stimulatory pathways to promote tumor genesis. As stimulatory checkpoint molecules, such as OX40, GITR, ICOS, 4-1BB and CD40, play key roles in regulating the effector functions of T cells, activating co-stimulatory pathways may improve checkpoint inhibition efficacy, and lead to durable antitumor responses.

Cat. No. Product Name / Synonyms Species Source
  • HY-P73499
    CD40 Protein, Human (193a.a, HEK293, His)

    Tumor Necrosis Factor Receptor Superfamily member 5; Bp50; CD40L Receptor; CDw40; TNFRSF5

    Human HEK293
  • HY-P7144
    CD40L/CD154/TRAP Protein, Human

    rHuCD40L; CD154; TRAP; TNFSF5; CD40LG; CD40-L

    Human E. coli
    CD40L/CD154/TRAP Protein, Human exerts an important role in immune system regulation, including myeloid progenitor cell development.
  • HY-P70609
    CD40L/CD154/TRAP Protein, Human (HEK 293)

    CD40 Ligand; CD40-L; T-Cell Antigen Gp39; TNF-Related Activation Protein; TRAP; Tumor Necrosis Factor Ligand Superfamily Member 5; CD154; CD40LG; CD40L; TNFSF5; TRAP

    Human HEK293
  • HY-P70614
    CD28 Protein, Mouse (130a.a, HEK 293, Fc-His)

    T-cell-specific surface glycoprotein CD28; CD28

    Mouse HEK293
  • HY-P75407
    CD40L/CD154/TRAP Protein, Canine (HEK293)

    CD40 ligand; CD40-L; TRAP; CD154; sCD40L; TNFSF5

    Canine HEK 293
  • HY-P71989
    CD40L/CD154/TRAP Protein, Human

    CD 40L; CD154; CD40 antigen ligand; CD40 ligand; CD40 ligand; soluble form; CD40-L; CD40L; CD40L_HUMAN; CD40LG; gp39; hCD40L; HIGM1; IGM; IMD3; T B cell activating molecule; T BAM; T-cell antigen Gp39; TNF-related activation protein; TNFSF5; TrAP; Tumor necrosis factor ligand; superfamily member 5; Tumor necrosis factor ligand superfamily member 5

    Human E. coli
  • HY-P73837
    LIGHT/TNFSF14 Protein, Mouse (sf9, His)

    Tumor necrosis factor ligand superfamily member 14; TNFSF14; HVEM-L; LIGHT  

    Mouse Sf9 insect cells
  • HY-P70479
    CD40 Protein, Human (173a.a, HEK 293, His)

    Tumor Necrosis Factor Receptor Superfamily member 5; B-Cell Surface Antigen CD40; Bp50; CD40L Receptor; CDw40; CD40; TNFRSF5

    Human HEK293
  • HY-P70829
    DNAM-1 Protein, Human (HEK293, Fc)

    CD226 antigen; DNAX accessory molecule 1; DNAM-1; CD226; DNAM1

    Human HEK 293
  • HY-P7113
    4-1BBL/TNFSF9 Protein, Human

    rHu4-1BBL/TNFSF9; CD137L

    Human E. coli
    4-1BBL/TNFSF9 Protein, Human is a costimulatory member of the TNF family, which are expressed on activated B cells, macrophages, and dendritic cells.
  • HY-P7401
    PVR/CD155 Protein, Human (323a.a, HEK293, Fc)

    rHuPVR/CD155, Fc Chimera; Poliovirus receptor; NECL-5; PVS

    Human HEK 293
    PVR/CD155 Protein, Human (323a.a, HEK293, Fc), a Type I transmembrane glycoprotein in the immunoglobulin superfamily, is involved in the cellular poliovirus infection in primates and intestinal humoral immune responses.
  • HY-P70187
    ICOS Protein, Rhesus macaque (HEK293,Fc)

    rRhInducible T-cell costimulator/ICOS, Fc ; Inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; CD278; AILIM; CVID1; ICOS

    Rhesus Macaque HEK 293
  • HY-P70476
    CD200 Protein, Human (HEK 293, His)

    OX-2 Membrane Glycoprotein; CD200; MOX1; MOX2

    Human HEK293
  • HY-P70486
    CD28 Protein, Human/Cynomolgus (HEK 293, His)

    CD28; CD28 antigen; CD28 molecule; T-cell-specific surface glycoprotein CD28; Tp44; TP44

    Human; Cynomolgus HEK293
  • HY-P70549
    OX40/TNFRSF4 Protein, Cynomolgus (HEK 293, His)

    Tumor necrosis factor receptor superfamily member 4; Tnfrsf4; OX40; CD134; Txgp1

    Cynomolgus HEK293
  • HY-P70550
    CD137/4-1BB Protein, Cynomolgus (HEK 293, His)

    CD137; ILA; TNFRSF9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA

    Cynomolgus HEK293
  • HY-P70609G
    GMP CD40L/CD154/TRAP Protein, Human (HEK 293)

    CD40 ligand; CD40-L; TRAP; CD154; TNFSF5

    Human HEK293
  • HY-P70622
    OX40 Ligand/TNFSF4 Protein, Human (HEK 293, His)

    Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFSF4; CD252; TXGP1

    Human HEK293
  • HY-P70678
    4-1BBR/TNFRSF9 Protein, Human (163a.a, HEK 293, His)

    CD137; ILA; TNFRSF9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA

    Human HEK293
    4-1BBR/TNFRSF9 Protein, Human (HEK 293, His) is a recombinant Human 4-1BBR/TNFRSF9 Protein expressed in HEK 293 cells with a His tag at the N-terminus. Recombinant Human 4-1BBRTNFRSF9, an inducible T cell molecule belonging to the TNF receptor superfamily, could promote the expansion of antigen-specific T cells and prevent activation-induced death of CD8+ T cells.
  • HY-P70681
    4-1BBR/TNFRSF9 Protein, Human (163a.a, HEK 293, Fc)

    CD137; ILA; TNFRSF9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA

    Human HEK293
    4-1BBR/TNFRSF9 Protein, Human (HEK 293, Fc), a recombinant human 4-1BBR/TNFRSF9 Protein produced in HEK293 cells, has an Fc fragment at the C-terminus. Recombinant Human 4-1BBRTNFRSF9, an inducible T cell molecule belonging to the TNF receptor superfamily, could promote the expansion of antigen-specific T cells and prevent activation-induced death of CD8+ T cells.
Cat. No. Product Name Effect Purity