2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Stimulatory Immune Checkpoint Molecules

Stimulatory Immune Checkpoint Molecules

Stimulatory Immune Checkpoint Molecules

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As opposed to inhibitory pathways that attenuate the immune system, co-stimulatory molecules augment immunological responses against malignant cells. Malignant cells often inhibit co-stimulatory pathways to promote tumor genesis. As stimulatory checkpoint molecules, such as OX40, GITR, ICOS, 4-1BB and CD40, play key roles in regulating the effector functions of T cells, activating co-stimulatory pathways may improve checkpoint inhibition efficacy, and lead to durable antitumor responses.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P73499
    CD40 Protein, Human (193a.a, HEK293, His)

    Tumor Necrosis Factor Receptor Superfamily member 5; Bp50; CD40L Receptor; CDw40; TNFRSF5

    		Human HEK293
  • HY-P70808
    CD40L/CD154/TRAP Protein, Mouse (HEK293, His)

    CD40 Ligand; CD40LG; HIGM1; T-B cell-activating molecule; T-BAM; TNFSF5; tumor necrosis factor (ligand) superfamily member 5; Tumor necrosis factor ligand superfamily member 5

    		Mouse HEK293
    CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway. CD40L also involves in B cell differentiation, maturation, and apoptosis. CD40L in mouse, cleaved into 2 chains of membrane form (1-260 a.a.) and soluble form (112-260 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Protein, Mouse (HEK293, His) has a total length of 149 amino acids (M112-L260), is expressed in HEK392 cells with N-terminal 6*His-tag.
  • HY-P70807
    PVR/CD155 Protein, Human (HEK 293, His)

    Poliovirus Receptor; Nectin-Like Protein 5; NECL-5; CD155; PVR; PVS

    		Human HEK293
    PVR/CD155 Protein, Human (HEK 293, His) is a recombinant Human PVR expressed in HEK 293 cells with a His tag at the N-terminus. PVR, Human plays a role in cancer cell invasion and migration.
  • HY-P72022
    SLAMF2/CD48 Protein, Human (194a.a, HEK293, hFc)

    B-lymphocyte activation marker BLAST-1 BCM1 surface antigen; Leukocyte antigen MEM-102; SLAM family member 2; SLAMF2; Signaling lymphocytic activation molecule 2; TCT.1; CD48; BCM1; BLAST1;

    		Human HEK293
  • HY-P70651
    B7-1/CD80 Protein, Human (208a.a, HEK293, His)

    CD80; Activation B7-1 antigen; B7; BB1; CD28LG1; CD28LGB7-1 antigen; T-lymphocyte activation antigen CD80

    		Human HEK293
  • HY-P70762
    CD28 Protein, Human/Cynomolgus (HEK 293, Fc)

    CD28; CD28 antigen; CD28 molecule; T-cell-specific surface glycoprotein CD28; Tp44; TP44

    		Human; Cynomolgus HEK293
  • HY-P72028
    CD40L/CD154/TRAP Protein, Human (HEK293, hFc-Flag)

    CD40-L; T-cell antigen Gp39; NF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5; CD154; sCD40L;

    		Human HEK293
    CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway. CD40L also involves in B cell differentiation, maturation, and apoptosis. CD40L in human, cleaved into 2 chains of membrane form (1-261 a.a.) and soluble form (113-261 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Protein, Human (HEK293, hFc-Flag) has a total length of 248 amino acids (M13-L261), is expressed in HEK392 cells with N-terminal hFc- and Flag-tag.
  • HY-P72353
    CD28 Protein, Human/Cynomolgus (Biotinylated, HEK293, Fc-Avi)

    CD28; CD28 antigen; CD28 molecule; T-cell-specific surface glycoprotein CD28; Tp44; TP44

    		Human; Cynomolgus HEK293
  • HY-P72839
    B7-H6 Protein, Human (HEK293, Fc)

    Natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1

    		Human HEK293
  • HY-P7317
    4-1BB/TNFRSF9 Protein, Human (CHO, Fc)

    rHu4-1BB, Fc Chimera; CD137; ILA

    		Human CHO
    4-1BB (CD137; TNFRSF9), a receptor of TNFSF9/4-1BBL, belongs to the tumor necrosis factor (TNF) receptor superfamily. 4-1BB is helpful for T cell activation and development, and also induces peripheral mononuclear cell proliferation and migration to the tumor microenvironment. 4-1BB is also involved in enhancing Nrf2 and NF-κB pathway mediated apoptosis of endothelial cells. Human 4-1BB protein is a surface glycoprotein with a transmembrane domain (187-213 a.a.). 4-1BB/TNFRSF9 Protein, Human (CHO, Fc) is the extracellular part (L24-Q186) of 4-1BB protein, produced by HEK293 cells with C-terminal hFc-tag.
  • HY-P7321
    B7-1/CD80 Protein, Human (HEK293, Fc)

    rHuB7-1/CD80, Fc Chimera; BB1; CD28LG; CD28LG1; LAB7

    		Human HEK293
    B7-1/CD80 Protein, Human (HEK293, Fc) is a polypeptide chain with the C-termimal human IgG1 Fc fragment produced in HEK293 cells. CD80 is a costimulatory molecule known for its role in T-cell activation and also in regulating normal and malignant B cellsactivity.
  • HY-P7324
    B7-H2/ICOSLG Protein, Human (240a.a, HEK293, Fc)

    rHuB7-H2/ICOSLG, Fc Chimera; B7 homolog 2; B7RP-1; CD275

    		Human HEK293
    B7-H2/ICOSLG Protein, Human (HEK293, Fc) is a polypeptide chain containing the C-termimal human IgG1 Fc fragment produced in HEK293 cells. ICOSLG is a number of the B7 family of co-stimulatory molecules.
  • HY-P7325
    B7-H2/ICOSLG Protein, Human (HEK293, His)

    rHuB7-H2/ICOSLG, His; B7 homolog 2; B7RP-1; CD275

    		Human HEK293
    B7-H2/ICOSLG Protein, Human (HEK293, His) is a polypeptide chain containing the C-termimal His tag produced in HEK293 cells. ICOSLG is a number of the B7 family of co-stimulatory molecules.
  • HY-P7631
    B7-H6 Protein, Human (HEK293, His)

    rHuB7-H6, His; B7 homolog 6; B7-H6; NCR3LG1; Natural cytotoxicity triggering receptor 3 ligand 1

    		Human HEK293
    B7-H6 Protein, Human (HEK293, His) suppresses the initiation of the “caspase cascade” and induces anti-apoptosis by STAT3 pathway activation to provoke tumorigenesis.
  • HY-P77599
    CD200R1 Protein, Human (HEK293, Fc)

    CD200R; CRTR2; MOX2R; OX2R; CD200 R1; CD200 receptor 1; HCRTR2; MOX2 receptor

    		Human HEK293
  • HY-P77601
    CD200R1 Protein, Human (Biotinylated, HEK293, His-Avi)

    CD200R; CRTR2; MOX2R; OX2R; CD200 R1; CD200 receptor 1; HCRTR2; MOX2 receptor

    		Human HEK293
  • HY-P7780
    Nectin-2/CD112 Protein, Human (HEK293, His)

    rHuCD112, His; Poliovirus Receptor-Related Protein 2; Herpes Virus Entry Mediator B; Herpesvirus Entry Mediator B; CD112; PVRL2; HVEB; PRR2

    		Human HEK293
    CD112 Protein, Human (HEK293, His) is a recombinant human CD112 expressed in HEK 293 cells with a His tag at the N-terminus. Recombinant Human CD112 can be used as cell surface ligands for the human DNAM-1 (CD226) activating molecule.
  • HY-P78063
    B7-1/CD80 Protein, Human (Biotinylated, HEK293, His-Avi)

    CD80 molecule; B7; B71; B7-1; BB1; CD28LG1; CD80; B7.1; CD28LG1; LAB7

    		Human HEK293
  • HY-P78064
    B7-2/CD86 Protein, Human (Biotinylated, HEK293, His-Avi)

    CD86 molecule; CD86; B70; B7-2 antigen; B72; B7-2; BU63; FUN-1; LAB72; MGC34413; CD28LG2

    		Human HEK293
  • HY-P78075
    B7-H2/ICOSLG Protein, Human (Biotinylated, HEK293, His-Avi)

    CD275; B7H2; B7-H2; B7RP-1; GL50; ICOSL; ICOS-L; ICOSLG; B7RP1; LICOS; ICOS ligand; B7-H2B7-related protein 1; B7RP-1; B7RP1B7-like protein Gl50

    		Human HEK293
Cat. No. Product Name Effect Purity