1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-4

IL-4

Interleukin-4 (IL-4) is a multipotent cytokine involved in the regulation of immune response. IL-4 is secreted mainly by mast cells, T cells, eosinophils and basophils, and is the receptor of IL-4 RA[1]. The effect of IL-4 depends on the type of shared receptor gamma chain (γc) that its receptor IL-4 RA recruits. IL-2Rγ is a common subunit of several interleukin receptors. (1) IL-4 RA recruits IL-2Rγ and forms a Type I signaling complex with IL-4 expressed on hematopoietic cells, leading to a series of receptor-related kinase-mediated phosphorylation events. More importantly, IL-2Rγ is also involved in the stimulating effect of IL-15 on neutrophil phagocytosis. Moreover, the IL-4 receptor complex further leads to recruitment of mediators for cell growth, anti-apoptosis, gene activation, and differentiation. However, (2) IL-4 RA recruits the IL-13RA1 chain and forms a Type II complex expressed on non-hematopoietic cells. It may stimulate autophagy of dendritic cells by interfering with mTORC1 signaling pathway and inducing RUFY4. In addition, IL-13RA1 plays a vital role in higher functions of the normal brain, such as memory and learning[2][3].
Specifically, IL-4 is involved in regulating the differentiation of antigen-stimulated naive T cells to produce IL-4 and other cytokines, including IL-5, IL-10, and IL-13. At the same time, it also inhibits the appearance of CD4+ of IFN-γ producing cells and prolongs the life of T and B lymphocytes under culture conditions. Secondly, IL-4 also controls immunoglobulin conversion and is involved in allergic regulation. It determines the conversion of human B cells to express IgE and IgG4, or mouse B cells to express IgE and IgG1. IL-4 also increases the expression of Class II MHC molecules and CD23 in B cells to participate in the immune response. IL-4 also plays an important role in tissue adhesion and inflammation. In conjunction with TNF, it induces the expression of vascular endothelial cell adhesion molecule-1 (VCAM-11) on vascular endothelial cells and down-regulates the selectin. IL-4 also plays a protective immune role induced by worms and other extracellular parasites[1].

Cat. No. Product Name / Synonyms Species Source
  • HY-P7080
    IL-4 Protein, Mouse (CHO)

    rMuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

    Mouse CHO
    IL-4 Protein, Mouse (CHO) is a species-specific cytokine which promotes the proliferation, differentiation and cell-surface protein modulation of B lymphocytes.
  • HY-P70750G
    GMP IL-4 Protein, Human (HEK293)

    Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4

    Human HEK293
    GMP IL-4 Protein, Human (HEK293) is a recombinant GMP-grade protein produced by HEK293 cells with C-His tag. IL-4 is an anti-inflammatory cytokine acting as a pleiotropic regulator of numerous immune and inflammatory processes.
  • HY-P7042
    IL-4 Protein, Human (CHO)

    rHuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

    Human CHO
    IL-4 Protein, Human (CHO) is a CHO cell derived, potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells.
  • HY-P70445
    IL-4 Protein, Human

    Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4

    Human E. coli
    IL-4 Protein, Human is a potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells.
  • HY-P70653
    IL-4 Protein, Mouse (HEK293, His)

    Interleukin-4; IL-4; IL4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Lymphocyte stimulatory factor 1

    Mouse HEK293
    IL-4 Protein, Mouse (HEK293, His) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 Protein, Mouse (HEK293, His) is a recombinant mouse interleukin-4 (rhIL-4) expressed in HEK 293 cells with a His tag.
  • HY-P70750
    IL-4 Protein, Human (HEK293)

    Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4

    Human HEK293
    IL-4 Protein, Human (HEK293) is a potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells. IL-4 Protein, Human (HEK293) is a recombinant human interleukin-4 (rhIL-4) expressed in HEK 293 cells.
  • HY-P70764
    IL-4 Protein, Human (HEK293, His)

    Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4

    Human HEK293
    IL-4 Protein, Human (HEK293, His) is a potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells. IL-4 Protein, Human (HEK293, His) is a recombinant human interleukin-4 (rhIL-4) expressed in HEK 293 cells with a His tag.
  • HY-P73215
    IL-4 Protein, Mouse (Q136D, Y139D, sf9, His)

    Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1

    Mouse Sf9 insect cells
  • HY-P78153
    IL-4 Protein, Human (Biotinylated, HEK293, His-Avi)

    IL4; IL-4; interleukin 4; MGC79402; pitrakinra; B cell growth factor 1; BCDF; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; BSF-1

    Human HEK293
  • HY-P78549
    GMP IL-4 Protein, Human

    Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4

    Human E. coli
  • HY-P700130AF
    Animal-Free IL-4 Protein, Human (His)

    Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4

    Human E. coli
  • HY-P700214AF
    Animal-Free IL-4 Protein, Mouse (His)

    rMuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

    Mouse E. coli
  • HY-P70653A
    IL-4 Protein, Mouse (HEK293, C-His)

    Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; IGG1 induction factor; Lymphocyte stimulatory factor 1; IL-4; BSF-1

    Mouse HEK293
  • HY-P70644
    IL-4 Protein, Mouse

    Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; IGG1 induction factor; Lymphocyte stimulatory factor 1; IL-4; BSF-1

    Mouse E. coli
    IL-4 Protein, Mouse is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression.
  • HY-P7219
    IL-4 Protein, Porcine (CHO)

    rPoIL-4; BSF-1; IL4

    Porcine CHO
    IL-4 Protein, Porcine (CHO) is the prime anti-infalmmatory cytokine involves in cell proliferation, various gene expression and avert apoptosis in IL-4 expressing cells.
  • HY-P73214
    IL-4 Protein, Canine

    Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1

    Canine E. coli
  • HY-P78466
    IL-4 Protein, Human (HEK293, His-Avi)

    IL4; IL-4; interleukin 4; MGC79402; pitrakinra; B cell growth factor 1; BCDF; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; BSF-1

    Human HEK293
  • HY-P77510
    IL-4 Protein, Human (Biotinylated)

    Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1

    Human E. coli
  • HY-P700748
    IL-4 Protein, Cynomolgus (HEK293, His)

    IL4; IL-4; interleukin 4; MGC79402; pitrakinra; B cell growth factor 1; BCDF; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; BSF-1

    Cynomolgus HEK293
  • HY-P71859
    IL-4 Protein, Rhesus macaque

    IL4Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1

    Rhesus Macaque E. coli
Cat. No. Product Name Effect Purity