1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. C Chemokines

The C chemokine subfamily (or γ chemokines) lacks the first and third cysteines and thus possesses only a single cysteine residue in the conserved position. This subfamily is composed of two members, XCL1 (also known as lymphotactin, Ltn, ATAC, SCYC-1, or SCM1-α), and XCL2 (SCM1-β, SCYC-2). XCL1 and XCL2 are produced by activated NK cells, CD8 T cells, γδ T cell and NKT cells. Structurally, XCL1 and XCL2 are very similar, exchanging between the monomeric chemokine fold and an unrelated dimeric state under physiological NaCl and temperature conditions. Binding of the XCL1 and XCL2 to the XCR1 receptor is considered to fix the conformation of XCR1 in an active state, which facilitates the receptor to interact with and activate heterotrimeric G proteins through the GDP/GTP exchange. This results in the dissociation of the G alpha subunit and the G beta-gamma subunits, leading to activation of downstream signaling pathways. XCL1 and XCL2 engagement of XCR1 triggers a variety of cellular responses including intracellular Ca 2+ flux and chemotaxis/chemokinesis.

Cat. No. Product Name / Synonyms Species Source
  • HY-P71434
    Lymphotactin/XCL1 Protein, Human (HEK293, Fc-His)

    Lymphotactin; ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1; LTN; SCYC1 and XCL1

    Human HEK293
    XCL1, a C class chemokine also known as Lymphotactin, is mainly produced by activated CD8+ T cells and natural killer cells. XCL1 signals by binding to the XCR1 receptor. XCL1 is involved in infectious, inflammatory and immunological diseases. Lymphotactin/XCL1 Protein, Human (HEK293, Fc-His) is produced in HEK293 cells with six C-Terminal His-tags and a C-Terminal Fc-tag. It consists of 93 amino acids (V22-G114).
  • HY-P7234
    Lymphotactin/XCL1 Protein, Human

    rHuLymphotactin/XCL1; ATAC; SCYC1

    Human E. coli
    XCL1, a C class chemokine also known as Lymphotactin, is mainly produced by activated CD8+ T cells and natural killer cells. XCL1 signals by binding to the XCR1 receptor. XCL1 is involved in infectious, inflammatory and immunological diseases. Lymphotactin/XCL1 Protein, Human (HEK293, Fc-His) is produced in E. coli, and consists of 92 amino acids (G23-G114).
  • HY-P74461
    XCL2/SCM-1 beta Protein, Human (sf9, His)

    Cytokine SCM-1 beta; C motif chemokine 2; XCL2; SCYC2

    Human Sf9 insect cells
    XCL2 (also knowns as SCM1-β and SCYC-2) is a member of C chemokine sub-family that is highly related to XCL1. XCL2 binds and activates the G protein-coupled receptor, XCR1. XCL2 is mainly produced by activated T cells and natural killer cells. XCL2/SCM-1 beta Protein, Human (sf9, His) is produced in sf9 insect cells with a C-Terminal His-tag. It consists of 114 amino acids (M1-G114).
  • HY-P77071
    Lymphotactin/XCL1 Protein, Canine (sf9, His)

    ATAC; C motif chemokine 1; Cytokine SCM-1; SCM-1-alpha; LTN; SCYC1

    Canine Sf9 insect cells
    XCL1, a C class chemokine also known as Lymphotactin, is mainly produced by activated CD8+ T cells and natural killer cells. XCL1 signals by binding to the XCR1 receptor. XCL1 is involved in infectious, inflammatory and immunological diseases. Lymphotactin/XCL1 Protein, Canine (sf9, His) is produced in sf9 cells with a C-Terminal His-tag. It consists of 112 amino acids (M1-T112).
  • HY-P77072
    Lymphotactin/XCL1 Protein, Cynomolgus (sf9, His)

    ATAC; C motif chemokine 1; Cytokine SCM-1; SCM-1-alpha; LTN; SCYC1

    Cynomolgus Sf9 insect cells
    XCL1, a C class chemokine also known as Lymphotactin, is mainly produced by activated CD8+ T cells and natural killer cells. XCL1 signals by binding to the XCR1 receptor. XCL1 is involved in infectious, inflammatory and immunological diseases. Lymphotactin/XCL1 Protein, Cynomolgus (sf9, His) is produced in sf9 cells with a C-Terminal His-tag. It consists of 114 amino acids (M1-G114).
Cat. No. Product Name Effect Purity