1. Immunology/Inflammation
  2. Salt-inducible Kinase (SIK)

Salt-inducible Kinase (SIK)

Salt-inducible Kinases (SIK) are a family of related serine-threonine kinases. In cultured adrenocortical cells, SIK1 is rapidly but transiently induced by adrenocorticotropin (ACTH) treatment, suggesting that it contributes to ACTH-mediated induction of steroidogenic enzymes. SIK2 is found in adipocytes and phosphorylates a specific serine residue. Members of the SIK family are emerging as important modulators of key processes such as steroid hormone biosynthesis by the adrenal cortex in adipocytes.

Salt-inducible Kinase (SIK) Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-15776
    HG-9-91-01 Inhibitor 98.17%
    HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
  • HY-101147
    YKL-05-099 Inhibitor 99.76%
    YKL-05-099 is a salt-inducible kinase (SIK) probe. YKL-05-099 binds to SIK1 and SIK3 with IC50s of ~10 and ~30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC50=40 nM).
  • HY-120856
    ARN-3236 Inhibitor 98.12%
    ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC50s of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. Has anti-cancer activity.
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