EphA3
EphA3, formerly known as HEK or EK5, is an EphA-class receptor expressed on hematopoietic progenitors, tissue stroma and vasculature and, notably, on stromal and tumor-infiltrating cells of several malignancies, while being largely absent from most normal adult tissues. Its ligands include ephrin-A2 and ephrin-A5, and activation drives cytoskeletal changes affecting cell morphology, adhesion and migration. EphA3 influences lung alveolar development and cardiac remodeling after injury, and its restricted tumor-stroma expression has made it a target of the monoclonal antibody ifabotuzumab in trials for acute myeloid leukemia and mesothelioma. Recombinant EphA3 proteins support these antibody and ligand-binding studies.
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EphA3 Protéines Recombinantes (9)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
