- Recombinant Proteins
- Cytokines and Growth Factors
- TGF-beta Superfamily
- Growth Differentiation Factor
Growth Differentiation Factor
Growth differentiation factors (GDFs) are a subfamily of the TGF-β superfamily, secreted as disulfide-linked dimers processed from pre-pro-proteins, that signal through serine/threonine kinase receptor complexes to SMAD pathways. Numbered GDF1 through GDF15, they display astonishing functional diversity: GDF1, GDF3 and GDF7 pattern the embryonic axis and neural crest; GDF5, GDF6 and GDF7 (BMP-12/13/14) are the cardinal skeletal morphogens governing joint, cartilage and tendon formation, with GDF5 mutations causing brachydactyly and synostosis syndromes; GDF8 (myostatin) is the master negative regulator of skeletal muscle mass; GDF9 and BMP-15 govern oocyte-granulosa communication and female fertility; GDF10 (BMP-3b) modulates bone density and axon guidance; GDF11 drives forebrain development and has controversial roles in aging; GDF15 acts on GFRAL in the brainstem to suppress appetite and mediate sickness anorexia. GDFs are accordingly targeted in muscle wasting (myostatin blockers), osteoarthritis (GDF5) and cachexia (GDF15 axis).
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Growth Differentiation Factor Recombinant Proteins (32)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
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