GDF-15 Protein, Canine (His)
Based on 1 Customer Validation
GDF-15 protein is an important member of the TGF-β family and plays a crucial role in cell growth, differentiation and immune regulation. His research has enhanced our understanding of the signaling pathways associated with the TGF-β superfamily and provided insights into its unique contribution to cellular homeostasis. GDF-15 Protein, Canine (His) is the recombinant canine-derived GDF-15 protein, expressed by E. coli , with N-His labeled tag.
- Species: Canine
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
GDF-15 protein is an important member of the TGF-β family and plays a crucial role in cell growth, differentiation and immune regulation. His research has enhanced our understanding of the signaling pathways associated with the TGF-β superfamily and provided insights into its unique contribution to cellular homeostasis. GDF-15 Protein, Canine (His) is the recombinant canine-derived GDF-15 protein, expressed by E. coli , with N-His labeled tag.
Background
The GDF-15 Protein is a significant member of the TGF-beta family, underscoring its crucial role in diverse cellular processes, including cell growth, differentiation, and immune regulation. As part of this family, GDF-15 likely shares conserved structural and functional features with related proteins, emphasizing its involvement in signaling pathways associated with the TGF-beta superfamily. The classification within the TGF-beta family underscores its specific designation within the broader context of growth factors, providing insights into its unique contributions to cellular homeostasis. The study of GDF-15 contributes to our understanding of its role in various physiological and pathological conditions, offering potential applications in cancer research, inflammation, and metabolic disorders. Further exploration of GDF-15's role holds promise for enhancing our knowledge of its contributions to both normal physiology and disease states.
Verified Bioactivity
1. Immobilized Canine GDF15, His Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-GDF15 Antibody, hFc Tag with the EC50 of 6.7 ng/ml determined by ELISA.
2. Immobilized Canine GDF15, His Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Human GFRAL, hFc Tag with the EC50 of 48.3 ng/mL determined by ELISA.
Technical Parameters
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Species Canine
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Source E. coli
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Tag N-8*His
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Accession
A0A8C0TNP6 (A197-V307)
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Molecular Construction
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N-term
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8*His
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GDF-15 (A197-V307)
Accession # A0A8C0TNP6 -
C-term
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Protein Length
Full Length of Cystine-knot cytokine
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Synonyms
GDF15; Placental Bone Morphogenetic Protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 Protein; NAG-1; NSAID-Regulated Gene 1 Protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
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AA Sequence
ARDGCPLGEGRCCRLQSLRASLQDLGWANWVVAPRELDVRMCVGACPSQFRSANTHAQMQARLHGLNPDAAPAPCCVPASYEPVVLMHQDSDGRVSLTPFDDLVAKDCHCV
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Predicted Molecular Mass
13.1 kDa
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Molecular Weight
Approximately 15-20 kDa under reduced (R) conditions, 23-26 kDa under non reducing (N) conditions, based on SDS-PAGE.
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 50 mM HAc, pH 2.9, 8% trehalose.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in 50 mM HAc.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (236 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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