Furin
Furin
Furin belongs to the proprotein convertase (PC) family. Furin is able to recognize specific amino acid sequences and cleave the protein precursors at these sequences, thereby converting inactive precursor proteins into mature proteins with functional activity. Furin is involved in the processing and maturation of intracellular proteins, such as coagulation factor Ⅷ and angiotensinogen. By cleaving cell surface receptors and signaling molecules, Furin participates in cell signaling transduction and regulates various vital activities of cells, such as cell proliferation, differentiation, and apoptosis. In addition, during viral infections, Furin can cleave the glycoproteins on the surface of the virus, promoting the fusion of the virus with the host cell membrane and facilitating the entry of the virus into the host cell. Furin plays an important role in a variety of diseases, including cardiovascular diseases, tumors, neurodegenerative diseases, and infectious diseases[1][2].
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Furin Verwandte Produkte (12)
Verwandte Produkte (12)
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Antibodies (2)
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Boc-Arg-Val-Arg-Arg-AMC hydrochloride
0 ImagesSynonyms: Boc-RVRR-AMCBoc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin.
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DEC-RVRK-CMK TFA
0 ImagesArt. -Nr.: HY-P5062AReinheit: 99.04%Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFADEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position.
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SSM3 tetraTFA hydrate
0 ImagesArt. -Nr.: HY-110147BReinheit: 99.9%SSM-3 tetraTFA hydrate is a potent furin inhibitor with an EC50 of 54 nM. SSM-3 tetraTFA hydrate uses its positively charged guanidyl group to form strong electrostatic interactions with the negatively charged residues in the catalytic center of furin, thereby competitively occupying and blocking the active site. SSM-3 tetraTFA hydrate can be used in the research of anthrax and avian influenza.
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DEC-RVRK-CMK
0 ImagesArt. -Nr.: HY-P5062CAS. Nr.: 534615-50-4Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketoneDEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position.
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PAI-1-IN-1
0 ImagesPAI-1-IN-1 is an orally active and specific PAI-1 inhibitor with an IC50 of <6.95 μM. PAI-1-IN-1 blocks the interaction between PAI-1 and serine proteases or LRP-1, and enhances plasmin generation. PAI-1-IN-1 restores macrophage efferocytosis and promotes macrophage polarization. PAI-1-IN-1 alleviates PAI-1-mediated inhibition of Furin, promotes MT1-MMP maturation, activates the NOTCH1 signaling pathway, inhibits proliferation and induces apoptosis. PAI-1-IN-1 promotes skeletal muscle regeneration and alleviates inflammation in a mouse model of skeletal muscle injury. PAI-1-IN-1 can be used in research on skeletal muscle injury-induced inflammation and chronic myeloid leukemia.
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SSM3 tetraTFA
0 ImagesArt. -Nr.: HY-110147ACAS. Nr.: 2320930-10-5SSM-3 tetraTFA is a potent furin inhibitor with an EC50 of 54 nM. SSM-3 tetraTFA uses its positively charged guanidyl group to form strong electrostatic interactions with the negatively charged residues in the catalytic center of furin, thereby competitively occupying and blocking the active site. SSM-3 tetraTFA can be used in the research of anthrax and avian influenza.
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PAI-1
0 ImagesArt. -Nr.: HY-P11413CAS. Nr.: 139446-70-1PAI-1 is a serine protease inhibitor (SERPIN). PAI-1 binds to and irreversibly inhibits uPA, tPA and furin; it also interacts with vitronectin, α1-acid glycoprotein, CRT, TLR4, proteasome α-3 subunit, uPAR, LRP1, Integrin αvβ3 and thrombin. PAI-1 regulates fibrinolysis, extracellular matrix turnover, cell migration, angiogenesis, inflammatory response and tissue remodeling; it mediates epithelial-mesenchymal transition (EMT)/endothelial-mesenchymal transition (EndMT), apoptosis and thrombus stabilization. PAI-1 can be used in research related to sepsis, acute lung injury, cardiovascular diseases, tissue fibrosis, diabetic nephropathy, obstructive nephropathy and non-insulin-dependent diabetes mellitus.
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Furin-IN-3
0 ImagesArt. -Nr.: HY-180145CAS. Nr.: 3080672-14-3
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Furin Substrate
0 ImagesArt. -Nr.: HY-P3797CAS. Nr.: 174838-79-0
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SSM-3
0 ImagesArt. -Nr.: HY-110147CAS. Nr.: 922732-52-3SSM-3 is a potent furin inhibitor with an EC50 of 54 nM. SSM-3 uses its positively charged guanidyl group to form strong electrostatic interactions with the negatively charged residues in the catalytic center of furin, thereby competitively occupying and blocking the active site. SSM-3 can be used in the research of anthrax and avian influenza.
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