534615-50-4
Chemical Structure
DEC-RVRK-CMK
Synonym(s): Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
- CAS No.: 534615-50-4
- Formula:C34H66ClN11O5
- Molecular Weight:744.41
InChIKey: GEJSMIRQBNBYGT-VZTVMPNDSA-N
SMILES: NCCCC[C@@H](C(CCl)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CCCCCCCCC)=O)=O)=O)=O
Biological Activity: DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position[1].
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DEC-RVRK-CMK | DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position. | |||||||||||||||||||||
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Keywords
