Signaling Pathway

Influenza Virus

Influenza Virus

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Influenza virus belong to the Orthomyxoviridae group, which are enveloped, segmented, single-stranded negative sense RNA viruses. The group includes three types of influenza viruses, A, B and C. Type B and C viruses only infect humans, but the type A viruses infect humans, horses, swine, other mammals, and a wide variety of domesticated and wild birds. Human influenza A and B viruses cause seasonal epidemics of disease almost every winter in the United States. The emergence of a new and very different influenza virus to infect people can cause an influenza pandemic. Influenza type C infections cause a mild respiratory illness and are not thought to cause epidemics. Each virus subtype has mutated into a variety of strains with differing pathogenic profiles; some are pathogenic to one species but not others, some are pathogenic to multiple species.

Influenza Virus Inhibitors & Modulators (17)

Product Name Catalog No. Brief Description
Amantadine hydrochloride

HY-B0402A

Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug.

Aprotinin

HY-P0017

Aprotinin is a 58 Amino Acid peptide protease inhibitor, used clinically to prevent postoperative blood loss and reduce transfusion requirements in those procedures which employ extracorporeal circulation.

Arbidol hydrochloride

HY-14904A

Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane
IC50 value:
Target: Antiviral; Anti-influenza agent
in vitro: Arbidol was found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with 50% inhibitory concentration (IC50) ranging from 2.7 to 13.8 microg/ml.

Dehydroandrographolide

HY-N0676

Dehydroandrographolide is extracted from herbal medicine Andrographis paniculata (Burm f) Nees; alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.

M2 ion channel blocker

HY-75867

This compound is capable of inhibiting and blocking the activity of M2 ion channel.

Moroxydine hydrochloride

HY-B0420A

Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.

Nitazoxanide

HY-B0217

Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent.

Nitazoxanide D4

HY-B0217S

Nitazoxanide D4 is the deuterium labeled Nitazoxanide, which is an antiprotozoal agent.

Nucleozin

HY-50001

Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication.

Oseltamivir acid

HY-13318

Oseltamivir acid (GS 4071; Ro 64-0802) is a metabolite of Oseltamivir.

Oseltamivir phosphate

HY-17016

Oseltamivir phosphate (GS-4104) is a competitive neuraminidase inhibitor, which is an antiviral drug.

Peramivir

HY-17015A

Peramivir (RWJ 270201; Rapiacta; BCX 1812) is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.

Peramivir trihydrate

HY-17015

Peramivir (RWJ 270201; Rapiacta; BCX 1812) is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.

Rimantadine

HY-B0338

Rimantadine (Flumadine) is an anti-influenza virus drug.

Rimantadine hydrochloride

HY-B0338A

Rimantadine Hcl (Flumadine) is an anti-influenza virus drug.

Theaflavin

HY-N0243

Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

Zanamivir

HY-13210

Zanamivir is an influenza viral neuraminidase inhibitor that is a structural analog of the sialic acid.