1. Anti-infection
  2. Bacterial
  3. Rifampicin

Rifampicin (Synonyms: Rifampin; Rifamycin AMP)

Cat. No.: HY-B0272 Purity: 98.07%
Handling Instructions

Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens.

For research use only. We do not sell to patients.

Rifampicin Chemical Structure

Rifampicin Chemical Structure

CAS No. : 13292-46-1

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10 mM * 1 mL in DMSO USD 75 In-stock
Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Rifampicin purchased from MCE. Usage Cited in: Onco Targets Ther. 2018 Sep 17;11:5885-5894.

    MHCC97-H cells are treated with the indicated concentrations of Rifampicin for 48 hours. Then, cells are harvested for Western blot analysis.

    Rifampicin purchased from MCE. Usage Cited in: Phytomedicine. 2019 Mar 15;56:175-182.

    Representative Western blots for P-gp、BCRP、MRP2 in LS-180 treated with six active compounds in liquorice. C: control, P-1: Rifampicin, P-2: Bosentan, S-1: Liquiritin, S-2: Liquiritigenin, S-3: Isoliquiritin, S-4: Isoliquiritigenin, S-5: Glycyrrhetinic acid, S-6: Licochalcone A.
    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens.

    In Vitro

    Rifampicin (100 mg/mL) can block the functional activity of P-glycoprotein. Rifampicin is not a substract for P-glycoprotein. The mechanism of rifampicin resistance is unassociated with the functional activity of P-glycoprotein[3].

    In Vivo

    Rifampicin (200, 400 mg/kg) can induce fatty liver at high concentration[1]. Rifampicin (30 mg/kg, i.p.) treatment of S464P biofilms in vivo results in a slight decline, but earlier rebinds in bioluminescence from these catheters compared with the parental signal, whereas rifampicin has no affect on bioluminescence in mice infected with mutant H481Y[2].

    Clinical Trial
    Molecular Weight

    822.94

    Formula

    C₄₃H₅₈N₄O₁₂

    CAS No.

    13292-46-1

    SMILES

    OC(C(/C=N/N1CCN(C)CC1)=C(NC(/C(C)=C\C=C\[[email protected]@H]([[email protected]@H]([[email protected]@H](C)[[email protected]]2O)O)C)=O)C(O)=C3C(O)=C4C)=C3C5=C4O[[email protected]](C)(O/C=C/[[email protected]@H]([[email protected]]([[email protected]@]([[email protected]@H]2C)([H])OC(C)=O)C)OC)C5=O

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (60.76 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2152 mL 6.0758 mL 12.1516 mL
    5 mM 0.2430 mL 1.2152 mL 2.4303 mL
    10 mM 0.1215 mL 0.6076 mL 1.2152 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 2.5 mg/mL (3.04 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (3.04 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [2]

    Briefly, 1 cm Teflon catheter (14-gauge) carrying 104 cfu S. aureus, either the parental strain Xen 29 or the RifR mutants S464P or H481Y, are implanted subcutaneously in groups of nine mice per strain. One catheter segment is inserted on each side of each animal. Six days after the implantation of the catheters, five mice from each group are treated with rifampicin at 30 mg/kg intraperitoneally in 0.1 mL saline, twice daily for four consecutive days. The remaining four mice in each group are left untreated as controls. At various time points during the infection, the mice are anaesthetized using a constant flow of 1.5% isoflurane from the IVIS® manifold, and imaged using an IVIS® Image System 100 Series. The bioluminescent signals (photons/s) emitted from the mice are analysed using LivingImage® software and plotted over the course of infection. The mice are sacrificed 20 days after infection (11 days after final rifampicin treatment). The catheters are surgically removed and the bacteria are detached by sonication for determination of bacterial burdens on the catheters.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: 98.07%

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