1. Screening Libraries
  2. Drug-Induced Liver Injury (DILI) Compound Library

Drug-Induced Liver Injury (DILI) Compound Library

Cat. No.: HY-L076
Library Contents: XLSX PDF SDF

Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug.

DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.

MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 893 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

MCE Drug-Induced Liver Injury (DILI) Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 877 compounds supplied in 10 mM solution, 13 compounds supplied in 2 mM solution and 3 compounds supplied in 3 mg/mL solution.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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50 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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2 × 100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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Description
& Advantages

•   A unique collection of 893 hepatotoxicity causing compounds for high throughput screening (HTS) and high content screening (HCS).

•   Including antibiotics, anti-cancer drugs, cardiac medications and anti-inflammatory agent, etc.

•   A useful tool for researching drug toxicity and mechanisms of DILI.

•   Including several different toxicities: steatosis, mitochondrial toxicity, cholestasis, drug allergy (hypersensitivity), etc.;

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 893 drug-induced liver injury compounds supplied as pre-dissolved Solutions or Solid
Solution: 877 compounds supplied in 10 mM solution, 13 compounds supplied in 2 mM solution, 3 compounds supplied in 3 mg/mL solution.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

Drug-Induced Liver Injury (DILI) Compound Library

Source: MedChem Express

Documentation

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    Product Name:
    Drug-Induced Liver Injury (DILI) Compound Library
    Cat. No.:
    HY-L076
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    • 96-well Plate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack