1. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cardiovascular Disease Related Products (1079):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13948
    Angiotensin II human 4474-91-3 99.96%
    Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.
    Angiotensin II human
  • HY-A0190
    Ceruletide 17650-98-5 99.96%
    Ceruletide, a biologically active decapeptide isolated from the skin of the Australian frog Hyla caerulea, is a potent cholecystokinetic agent, and acts as a cholecystokinin receptor agonist.
    Ceruletide
  • HY-19363
    GW4869 6823-69-4
    GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) with an IC50 of 1 μM.
    GW4869
  • HY-B0468
    Isoprenaline hydrochloride 51-30-9 >99.0%
    Isoprenaline hydrochloride is a non-selective beta-adrenergic receptor agonist with potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities.
    Isoprenaline hydrochloride
  • HY-101952
    Prostaglandin E2 363-24-6 98.36%
    Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
    Prostaglandin E2
  • HY-17502
    Simvastatin 79902-63-9 99.81%
    Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
    Simvastatin
  • HY-13441
    (-)-Blebbistatin 856925-71-8 99.42%
    (-)-Blebbistatin is an S enantiomer of blebbistatin. Blebbistatin is a potent and selective myosin II inhibitor with IC50s ranging from 0.5 to 5 μM.
    (-)-Blebbistatin
  • HY-A0064
    Verapamil hydrochloride 152-11-4 99.95%
    Verapamil hydrochloride is a calcium channel antagonist.
    Verapamil hydrochloride
  • HY-P0017
    Aprotinin 9087-70-1
    Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively.
    Aprotinin
  • HY-N0504
    Lovastatin 75330-75-5 99.47%
    Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
    Lovastatin
  • HY-13715B
    Norepinephrine bitartrate monohydrate 108341-18-0 99.75%
    Norepinephrine bitartrate monohydrate (Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate) is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.
    Norepinephrine bitartrate monohydrate
  • HY-19424
    Hemin 16009-13-5 >98.0%
    Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.
    Hemin
  • HY-B0284
    Nifedipine 21829-25-4
    Nifedipine (BAY-a-1040) is a potent calcium channel blocker and drug of choice for cardiac insufficiencies.
    Nifedipine
  • HY-13755
    Sulforaphane 4478-93-7 99.75%
    Sulforaphane is an isothiocyanate present naturally in widely consumed vegetables; has shown anticancer and cardioprotective activities.
    Sulforaphane
  • HY-B1049
    Digoxin 20830-75-5 98.99%
    Digoxin is a potent inhibitor of Na+/K+-ATPase, clinically used to treat arrhythmia and heart failure.
    Digoxin
  • HY-B0471
    (R)-(-)-Phenylephrine hydrochloride 61-76-7 98.10%
    (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
    (R)-(-)-Phenylephrine hydrochloride
  • HY-50903
    Rivaroxaban 366789-02-8 99.91%
    Rivaroxaban (BAY 59-7939) is a highly potent,selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM).
    Rivaroxaban
  • HY-12298
    Setanaxib 1218942-37-0 99.43%
    Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.
    Setanaxib
  • HY-17512
    Losartan 114798-26-4 99.24%
    Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
    Losartan
  • HY-D0187
    L-Glutathione reduced 70-18-8 99.83%
    L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
    L-Glutathione reduced