Antithrombin III
Antithrombin III (ATIII, Serpin C1) is the principal plasma anticoagulant serpin, synthesized in the liver and circulating as a glycoprotein. It inactivates thrombin, factor Xa and factor IXa by forming stable covalent complexes, and heparin or heparan sulfate binding to its N-terminal domain accelerates thrombin inhibition by several orders of magnitude through a conformational change. Inherited antithrombin deficiency causes autosomal dominant thrombophilia with recurrent venous thromboembolism, and acquired reductions occur in sepsis, liver disease and disseminated intravascular coagulation. Glycosylation heterogeneity influences heparin affinity and plasma half-life. Both plasma-derived and recombinant antithrombin are used clinically as anticoagulants and as standards in coagulation assays.
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Antithrombin III Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
