MMP-12
MMP-12, known as macrophage metalloelastase, is expressed almost exclusively by macrophages and endows them with the ability to degrade elastic fibers, a property central to its classic role in emphysema pathogenesis, long studied in smoker macrophages. Beyond elastin, the enzyme cleaves plasminogen to release the antiangiogenic fragment angiostatin, modulating angiogenesis, and contributes to atherosclerotic plaque remodeling where macrophages abound. Genetic deletion of Mmp12 in mice protects against cigarette-smoke-induced lung destruction, while human studies associate variants with emphysema susceptibility and abdominal aortic aneurysm. Because tumor-associated macrophages are often MMP-12-positive, the enzyme also serves as a marker of macrophage infiltration in several carcinomas.
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MMP-12 Recombinant Proteins (2)
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Inhibitors & Agonists (20)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
