2. Recombinant Proteins
  3. Ubiquitin Related Proteins
  4. Ubiquitin Enzymes
  5. E3 Ligases

E3 Ligases

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Protein ubiquitination is a refined post-translational modification ubiquitous in all eukaryotes that is required for many cellular processes, including protein degradation by the proteasome, cell cycle progression, transcriptional regulation, DNA repair and signal transduction. Ubiquitination is catalyzed by ubiquitin-activating (E1), ubiquitin-conjugating (E2) and ubiquitin ligase (E3) enzymes. E3s mediate the transfer of ubiquitin from an E2 enzyme to specific substrate proteins at the end of a three-enzyme cascade. E3s are the most heterogeneous class of enzymes in the ubiquitination pathway, as they mediate substrate specificity. They can be classified into two groups: 1) the single-subunit group, including several subfamilies based upon their mechanisms of action and the presence of specific domains: HECT (Homology to E6-AP C Terminus), RING (Really Interesting New Gene) and U-box type E3s; 2) the multi-subunit group, Cullin-RING box1-Ligases (CRLs), are further divided into four subfamilies: SCF (S phase kinase-associated protein 1–Cullin 1–F-box), BTB (Bric-a-brac–Tramtrack–Broad complex), DDB (DNA Damage-Binding domain-containing) and APC (anaphase-promoting complex). To date, >650 E3 ubiquitin ligases have been described in humans.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P73485
    XIAP Protein, Human (Avi)

    E3 ubiquitin-protein ligase XIAP; ILP; IAP-3; XIAP; API3; BIRC4

    		Human E. coli
  • HY-P73537
    XIAP Protein, Human (His)

    E3 ubiquitin-protein ligase XIAP; ILP; IAP-3; XIAP; API3; BIRC4

    		Human E. coli
  • HY-P71385
    TRIM5 Protein, Human (His)

    Tripartite motif-containing protein 5; RING finger protein 88; TRIM5; RNF88

    		Human E. coli
  • HY-P75894
    ITCH/AIP4 Protein, Human (solution)

    E3 ubiquitin-protein ligase Itchy homolog; AIP4; NAPP1; ITCH

    		Human E. coli
  • HY-P76008
    RNF43 Protein, Human (HEK293, His)

    E3 ubiquitin-protein ligase RNF43; RING finger protein 43; RNF43

    		Human HEK293
  • HY-P77507
    WWP2 Protein, Human (sf9, His-GST)

    NEDD4-like E3 ubiquitin-protein ligase WWP2; Atrophin-1-interacting protein 2; AIP2; WWP2

    		Human Sf9 insect cells
  • HY-P701593
    MDM2 Protein, Human

    MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2

    		Human E. coli
  • HY-P71385A
    TRIM5 Protein, Human (N-His)

    Tripartite motif-containing protein 5; RING finger protein 88; TRIM5; RNF88

    		Human E. coli
  • HY-P76007
    RNF43 Protein, Human (HEK293, Fc)

    E3 ubiquitin-protein ligase RNF43; RING finger protein 43; RNF43

    		Human HEK293
  • HY-P74343
    CBLC Protein, Human (sf9, His-GST)

    E3 ubiquitin-protein ligase CBL-C; CBLC; CBL3; RNF57

    		Human Sf9 insect cells
  • HY-P75970
    Pellino-1 Protein, Human (sf9, His-GST)

    E3 ubiquitin-protein ligase pellino homolog 1; PELI1; PRISM

    		Human Sf9 insect cells
  • HY-P78030
    RNF43 Protein, Mouse (HEK293, Fc)

    E3 ubiquitin-protein ligase RNF43; RING finger protein 43; RING-type E3 ubiquitin transferase RNF43; Rnf43

    		Mouse HEK293
  • HY-P700503
    TRIM24 Protein, Human (P. pastoris, His)

    TRIM24; tripartite motif containing 24; TIF1, transcriptional intermediary factor 1 , tripartite motif containing 24; transcription intermediary factor 1-alpha; hTIF1; RNF82; TIF1A; Tif1a; TIF1-alpha; RING finger protein 82; tripartite motif-containing 24; E3 ubiquitin-protein ligase TRIM24; transcriptional intermediary factor 1; PTC6; TF1A; TIF1; TIF1ALPHA;

    		Human P. pastoris
  • HY-P701512
    SMURF2 Protein, Human (His)

    SMURF2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2

    		Human E. coli
  • HY-P701513
    SMURF2 Protein, Human

    SMURF2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2

    		Human E. coli
  • HY-P701528
    HLTF Protein, Human

    HLTF; Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3

    		Human E. coli
  • HY-P701535
    BRAP Protein, Human

    BRAP; BRCA1-associated protein; BRAP2; Impedes mitogenic signal propagation; IMP; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; Renal carcinoma antigen NY-REN-63

    		Human E. coli
  • HY-P701548
    RNF114 Protein, Human

    RNF114; E3 ubiquitin-protein ligase RNF114; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; Zinc finger protein 228; Zinc finger protein 313

    		Human E. coli
  • HY-P701550
    RNF11 Protein, Human

    RNF11; RING finger protein 11

    		Human E. coli
  • HY-P701560
    RNF181 Protein, Human

    RNF181; E3 ubiquitin-protein ligase RNF181; RING finger protein 181

    		Human E. coli
Cat. No. Product Name Effect Purity