2. Recombinant Proteins
  3. Ubiquitin Related Proteins
  4. Ubiquitin Enzymes
  5. E3 Ligases
  6. ITCH Proteins

ITCH Proteins

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Cat. No. Product Name / Synonyms Species Source
  • HY-P75894
    ITCH/AIP4 Protein, Human (solution)

    E3 ubiquitin-protein ligase Itchy homolog; AIP4; NAPP1; ITCH

    		Human E. coli
    The ITCH/AIP4 protein, a member of the Nedd4 family of ubiquitin ligases, transfers ubiquitin to protein substrates for lysosomal degradation. It regulates cell differentiation and immune responses and is associated with autoimmune disease. Alternative splicing produces multiple isoforms. ITCH/AIP4 is expressed ubiquitously, with notable levels in the testis, esophagus, and 25 other tissues. ITCH/AIP4 Protein, Human (solution) is the recombinant human-derived ITCH/AIP4 protein, expressed by E. coli , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of ITCH/AIP4 Protein, Human (solution) is 378 a.a., with molecular weight of ~40 kDa.
  • HY-P75894A
    ITCH/AIP4 Protein, Human

    E3 ubiquitin-protein ligase Itchy homolog; AIP4; NAPP1; ITCH

    		Human E. coli
    ITCH/AIP4 Protein, an E3 ubiquitin-protein ligase, catalyzes 'Lys-29,' 'Lys-48,' and 'Lys-63'-linked ubiquitin conjugation, influencing inflammatory signaling pathways. It forms a ubiquitin-editing complex, promoting RIPK1 degradation and termination of TNF- or LPS-mediated NFKB1 activation. It regulates transcription factors, immune response, and hematopoietic lineage development. ITCH/AIP4 targets JUN, JUNB, DTX1, and MAVS for degradation, modulates Wnt receptor sorting, and controls CXCR4 trafficking. It also regulates apoptosis, reactive oxygen species levels, and inhibits influenza A virus replication. ITCH/AIP4 Protein, Human is the recombinant human-derived ITCH/AIP4 protein, expressed by E. coli , with tag free. The total length of ITCH/AIP4 Protein, Human is 378 a.a., with molecular weight of ~45 kDa.
Cat. No. Product Name Effect Purity