2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. CSF & Receptors
  5. G-CSF

G-CSF

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Granulocyte colony stimulating factor (G-CSF; CSF 3) is a pro-inflammatory cytokine which primarily stimulates the survival, proliferation, differentiation and function of neutrophil granulocyte progenitor cells and mature neutrophils. Human G-CSF is secreted mainly by monocytes and macrophages, but is also produced by endothelial cells, fibroblasts, and bone marrow stromal cells. G-CSF binds and activates its cognate receptor G-CSFR on neutrophils and their progenitors, which initiates downstream signaling cascades that include the Jak-STAT and MAP kinase pathways. G-CSF is a major regulator of neutrophil development and contributes to the regulation of multipotent hematopoietic progenitors. In addition, G-CSF also influences the phenotype and function of mature neutrophils and does so by modulating expression of for example chemokine receptors, up-regulating phagocytosis and production of reactive oxygen species (ROS) and enhancing bactericidal activity of neutrophils. It is worth mentioning that G-CSF is an FDA- and EMA- approved drug commonly used to treat neutropenia and to mobilize bone marrow hematopoietic stem cells for transplantation.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7015A
    G-CSF Protein, Human (CHO)

    rHuG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim

    		Human CHO
    G-CSF Protein, Human (CHO) is a polypeptide growth factor that regulates the production of neutrophilic granulocytes.
  • HY-P73073
    G-CSF Protein, Human (HEK293, Fc)

    Granulocyte Colony-Stimulating Factor; G-CSF; CSF3; C17orf33

    		Human HEK293
    G-CSF, a pivotal cytokine, regulates hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. This monomeric protein specifically promotes granulocyte development, playing a crucial role in immune system regulation and blood cell formation. G-CSF Protein, Human (HEK293, Fc) is the recombinant human-derived G-CSF protein, expressed by HEK293 , with N-hFc labeled tag. The total length of G-CSF Protein, Human (HEK293, Fc) is 174 a.a., with molecular weight of 45-50 kDa.
  • HY-P73523
    G-CSF Protein, Human (HEK293)

    Granulocyte Colony-Stimulating Factor; G-CSF; CSF3; C17orf33

    		Human HEK293
    G-CSF, a pivotal cytokine, regulates hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. This monomeric protein specifically promotes granulocyte development, playing a crucial role in immune system regulation and blood cell formation. G-CSF Protein, Human (HEK293) is the recombinant human-derived G-CSF protein, expressed by HEK293 , with tag free. The total length of G-CSF Protein, Human (HEK293) is 175 a.a., with molecular weight of ~17.8 kDa.
  • HY-P700083AF
    Animal-Free G-CSF Protein, Human (His)

    CSF-3; MGI-1G; GM-CSF beta; pluripoietin

    		Human E. coli
    G-CSF, a pivotal cytokine, regulates hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. This monomeric protein specifically promotes granulocyte development, playing a crucial role in immune system regulation and blood cell formation. Animal-Free G-CSF Protein, Human (His) is the recombinant human-derived animal-FreeG-CSF protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free G-CSF Protein, Human (His) is 174 a.a., with molecular weight of ~19.48 kDa.
  • HY-P700178AF
    Animal-Free G-CSF Protein, Mouse (His)

    rMuG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim

    		Mouse E. coli
    The G-CSF Protein, a monomeric cytokine in the granulocyte/macrophage colony-stimulating factor family, crucially regulates hematopoiesis by orchestrating the production, differentiation, and function of granulocytes and monocytes-macrophages. Its production emphasizes its significance in maintaining immune system balance and functionality. Animal-Free G-CSF Protein, Mouse (His) is the recombinant mouse-derived animal-FreeG-CSF protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free G-CSF Protein, Mouse (His) is 178 a.a., with molecular weight of ~19.76 kDa.
  • HY-P7068
    G-CSF Protein, Mouse (CHO)

    rMuG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim

    		Mouse CHO
    G-CSF Protein, Mouse (CHO) is a polypeptide growth factor that regulates the production of neutrophilic granulocytes.
  • HY-P70554
    G-CSF Protein, Mouse (HEK293, His)

    Granulocyte colony-stimulating factor; Csf3; G-CSF

    		Mouse HEK293
    The G-CSF Protein, a monomeric cytokine in the granulocyte/macrophage colony-stimulating factor family, crucially regulates hematopoiesis by orchestrating the production, differentiation, and function of granulocytes and monocytes-macrophages. Its production emphasizes its significance in maintaining immune system balance and functionality. G-CSF Protein, Mouse (HEK293, His) is the recombinant mouse-derived G-CSF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of G-CSF Protein, Mouse (HEK293, His) is 178 a.a., with molecular weight of 25-27 kDa.
  • HY-P70422
    G-CSF Protein, Human

    Granulocyte Colony-Stimulating Factor; G-CSF; Pluripoietin; Filgrastim; Lenograstim; CSF3; C17orf33; GCSF

    		Human E. coli
    G-CSF Protein, Human is a glycoprotein, acting to stimulate granulopoiesis, the innate immunity, and the differentiation of neural progenitor cells.
  • HY-P7093A
    G-CSF Protein, Rat (HEK293)

    rRtG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim

    		Rat HEK293
    G-CSF Protein, Rat (HEK293) is a glycoprotein, acting to stimulate granulopoiesis, the innate immunity, and the differentiation of neural progenitor cells.
  • HY-P71877
    CSF3 Protein, Rhesus macaque

    Granulocyte colony-stimulating factor; CSF3

    		Rhesus Macaque E. coli
    CSF3 Protein, a member of the IL-6 superfamily, is a vital granulocyte/macrophage colony-stimulating factor influencing hematopoiesis. It regulates the production, differentiation, and function of granulocytes and monocytes-macrophages, playing a key role in the intricate balance of hematopoietic processes. CSF3's significance within the IL-6 superfamily extends to orchestrating immune system components for optimal functionality. CSF3 Protein, Rhesus macaque is the recombinant Rhesus Macaque-derived CSF3 protein, expressed by E. coli , with tag free. The total length of CSF3 Protein, Rhesus macaque is 177 a.a., with molecular weight of ~18.9 kDa.
  • HY-P7015
    G-CSF Protein, Human (167a.a)

    rHuG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim

    		Human E. coli
    G-CSF Protein, Human (167a.a) is a polypeptide growth factor that regulates the production of neutrophilic granulocytes.
Cat. No. Product Name Effect Purity