2. Oligonucleotides
  3. Nucleosides and their Analogs

Nucleosides and their Analogs

Nucleosides are important biological molecules that function as signaling molecules and as precursors to nucleotides needed for DNA and RNA synthesis. Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (either ribose or deoxyribose). Examples of nucleosides include cytidine, uridine, adenosine, guanosine, thymidine and inosine.

Nucleosides and their Analogs (1129):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1449
    Uridine 58-96-8 99.99%
    Uridine (β-Uridine) is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.
    Uridine
  • HY-19528
    SAH 979-92-0 99.89%
    SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM.
    SAH
  • HY-14392
    5,6-Dichlorobenzimidazole riboside 53-85-0 99.95%
    5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK). 5, 6-dichlorobenzimidazole riboside has antitumor activity. 5, 6-dichlorobenzimidazole riboside can induce apoptosis.
    5,6-Dichlorobenzimidazole riboside
  • HY-N0097
    Guanosine 118-00-3 99.65%
    Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.
    Guanosine
  • HY-B0158
    Cytidine 65-46-3 99.61%
    Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine
  • HY-156714
    Biotin-PEG4-alkane-3',5'-cytidine-bisphosphate 1340586-70-0
    Biotin-PEG4-alkane-3',5'-cytidine-bisphosphate (BPA-3',5'-pCp) is a 把iotin-PEG4-alkane modified nucleotide (GB2479833A; compound 6).
    Biotin-PEG4-alkane-3',5'-cytidine-bisphosphate
  • HY-154646
    2',3,5'-Tri-O-benzoyl-4'-thiouridine 2072145-30-1
    2’,3’,5’-Tri-O-benzoyl-4’-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2',3,5'-Tri-O-benzoyl-4'-thiouridine
  • HY-113061
    Pseudouridine 1445-07-4 99.93%
    Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation.
    Pseudouridine
  • HY-112582
    N1-Methylpseudouridine 13860-38-3 99.95%
    N1-methyl-pseudouridine (1-Methylpseudouridine), a methylpseudouridine, outperforms 5 mC and 5 mC/N1-methyl-pseudouridine in translation. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density.
    N1-Methylpseudouridine
  • HY-19314A
    Azvudine hydrochloride 1333126-31-0
    Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains. Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Azvudine hydrochloride
  • HY-W011527
    Xanthosine 146-80-5 99.96%
    Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine can increase mammary stem cell population and milk production in cattle and goats.
    Xanthosine
  • HY-113135
    5-Methylcytidine 2140-61-6 99.72%
    5-Methylcytidine is a pyrimidine nucleoside detected in multiple biofluids.
    5-Methylcytidine
  • HY-W040329
    2'-Deoxyadenosine 958-09-8 99.99%
    2'-Deoxyadenosine is a nucleoside adenosine derivative, pairing with deoxythymidine (T) in double-stranded DNA.
    2'-Deoxyadenosine
  • HY-B0249
    Didanosine 69655-05-6 99.94%
    Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV.
    Didanosine
  • HY-10444
    R-1479 478182-28-4 99.60%
    R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM). R-1479 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    R-1479
  • HY-W009444
    5-Methyluridine 1463-10-1 99.87%
    5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids.
    5-Methyluridine
  • HY-10870
    RO-9187 876708-03-1 98.39%
    RO-9187 is a potent inhibitor of HCV virus replication with an IC50 of 171 nM. RO-9187 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    RO-9187
  • HY-13859
    Clevudine 163252-36-6 99.93%
    Clevudine (L-FMAU), a nucleoside analog of the unnatural L-configuration, has potent anti-HBV activity with long half-life, low toxicity. Clevudine is a non-competitive inhibitor that is not incorporated into the viral DNA but rather binds to the polymerase. Clevudine is active against cowpox virus respiratory infection in mice.
    Clevudine
  • HY-19314
    Azvudine 1011529-10-4 99.60%
    Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains. Azvudine is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Azvudine
  • HY-W054064
    6-Chloro-7-deazapurine-β-D-riboside 16754-80-6 98.06%
    Chloro-7-deazapurine-β-D-riboside is a nucleoside derivative and has antifungal activity.
    6-Chloro-7-deazapurine-β-D-riboside