2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Epigenetics
  3. Endogenous Metabolite Akt AMPK FOXO
  4. Xanthosine

Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Xanthosine

Xanthosine 構造式

CAS 番号 : 146-80-5

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
50 mg $50 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Other Forms of Xanthosine:

Xanthosine 関連抗体

Top Publications Citing Use of Products

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Human Endogenous Metabolite Microbial Metabolite

Akt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Akt Akt1 Akt2 Akt3

AMPK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

FOXO アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
FOXO1 FOXO3

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research[1][2][3][4][5][6].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外実験

Xanthosine (200 μM) increases the population of bovine mammary epithelial cells (MEC) during the exponential phase of cell growth, reduces the doubling time, promotes symmetric cell division[1].
Xanthosine (1.75-17.6 μM; 2 h) enhances glucose uptake, decreases glucose production, increases glycogen content, and activates AKT phosphorylation in FFA-induced CC1 hepatocytes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthosine 関連抗体

Western Blot Analysis[3]

Cell Line: CC1 hepatocytes treated with FFA
Concentration: 1.75 μM, 3.52 μM, 7.04 μM, 10.56 μM, 14.07 μM, 17.6 μM
Incubation Time: 2 h pretreatment
Result: Upregulated AMPK phosphorylation and downregulated PEPCK and G6Pase protein expression.
Dose-dependently upregulated FoxO1 phosphorylation at Ser256.
Increased AKT phosphorylation, GSK-3β phosphorylation at Ser9, and GS phosphorylation.
体内実験

Xanthosine (9.6 mg Xanthosine dehydrate dissolved in 300 μL PBS; i.p.; 14 consecutive days) has a latent negative effect on bovine mammary cell proliferation in immunodeficient mice with bovine mammary implants[2].
Xanthosine (up to 5 mg/kg) has no effect on the cat blood pressure[4].
Xanthosine (1.5-2 mL; 10 mM; intraductal infusion and parenchymal injection; 5 consecutive days) significantly increases the number of label-retaining epithelial cells (LREC) and telomerase activity in the mammary glands of female Holstein calves, indicating an expansion of the mammary stem cell population[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD-SCID mice (female, 3-week-old) with bovine mammary implants[2]
Dosage: 9.6 mg xanthosine dehydrate dissolved in 300 µL PBS pH 10
Administration: Intraperitoneal injection (i.p.), 14 consecutive days
Result: Did not affect the relative number of label-retaining epithelial cells (LRECs) in bovine mammary implants.
Showed no significant long-term or latent effect on the relative proportion of different cell populations in the bovine mammary implants, including stem cells.
Reduced the levels of PCNA-positive and BrdU-positive cells by 60% and 30%, respectively, after 11 weeks.
分子量

284.23

分子式

C10H12N4O6
CAS 番号
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(NC3=O)=O)=C3N=C2)O1
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 33.33 mg/mL (117.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5183 mL 17.5914 mL 35.1828 mL
5 mM 0.7037 mL 3.5183 mL 7.0366 mL
10 mM 0.3518 mL 1.7591 mL 3.5183 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.99%

COA (253 KB) HNMR (287 KB) RP-HPLC (206 KB) MS (68 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5183 mL 17.5914 mL 35.1828 mL 87.9569 mL
5 mM 0.7037 mL 3.5183 mL 7.0366 mL 17.5914 mL
10 mM 0.3518 mL 1.7591 mL 3.5183 mL 8.7957 mL
15 mM 0.2346 mL 1.1728 mL 2.3455 mL 5.8638 mL
20 mM 0.1759 mL 0.8796 mL 1.7591 mL 4.3978 mL
25 mM 0.1407 mL 0.7037 mL 1.4073 mL 3.5183 mL
30 mM 0.1173 mL 0.5864 mL 1.1728 mL 2.9319 mL
40 mM 0.0880 mL 0.4398 mL 0.8796 mL 2.1989 mL
50 mM 0.0704 mL 0.3518 mL 0.7037 mL 1.7591 mL
60 mM 0.0586 mL 0.2932 mL 0.5864 mL 1.4659 mL
80 mM 0.0440 mL 0.2199 mL 0.4398 mL 1.0995 mL
100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8796 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Xanthosine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xanthosine146-80-5Endogenous MetaboliteAktAMPKFOXOPKBProtein kinase BAMP-activated protein kinaseForkhead box Omammary cellcatLRECHolstein calvesMECInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Xanthosine
製品番号:
HY-W011527
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.