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High-Throughput Natural Product Library

Cat. No.: HY-L206

Natural products (NPs) are a class of widely bioactive compounds that have been shown to have a variety of uses, including pharmaceutical, agricultural, industrial and other fields. Historically, natural products have played a key role in drug discovery, particularly for cancer and infectious diseases, but also in other therapeutic areas, including cardiovascular disease (e.g., statins) and multiple sclerosis (e.g., Fingolimod). Compared to traditional synthetic molecules, natural products have special structure and function, which brings advantages and challenges to the drug discovery process. Compared to synthetic compounds, natural products have higher skeleton diversity, structural complexity, and generally have higher molecular mass, more sp3 carbon atoms and oxygen atoms, more hydrogen bond acceptors and donors, and so on. Overall, natural product libraries cover a broader chemical space than typical synthetic small molecules.

MCE provides a unique collection of 4,792 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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  • Biological Activity
  • Product Details
  • Composition

Description & Advantages

•   A unique collection of 4,792 natural products for high throughput screening (HTS) and high content screening (HCS).

•   The compounds in the library contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes.

•   A useful tool for drug discovery as an important source of lead compounds.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

Product Details

Formulation:

A collection of 4,792 natural products supplied as pre-dissolved Solutions or Solid
Solution: 4,622 compounds supplied in 10 mM solution, 127 compounds supplied in 2 mM solution, 43 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

Composition

NF-κB (236)

Fungal (173)

COX (100)

Akt (85)

ERK (62)

HIV (57)

PI3K (50)

STAT (48)

PPAR (44)

MMP (38)

AMPK (33)

JNK (32)

HSV (30)

PKC (30)

mTOR (28)

iGluR (25)

PARP (23)

HBV (19)

nAChR (19)

Wnt (19)

EGFR (17)

mAChR (17)

JAK (16)

HDAC (12)

PKA (12)

CDK (11)

Related Service
Recommendation
Compound Customization
  •  Specific Compounds
  •  Quantities
  •  Plate Map
  •  Concentration
  •  Form (Solid or Solution)
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    Product Name:
    High-Throughput Natural Product Library
    Cat. No.:
    HY-L206
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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