2. Biochemical Assay Reagents
  3. Chelators

Chelators

Chelators refer to a class of compounds capable of forming complexes with metal ions. They contain two or more ligands that react with metal ions to form stable chelates. Typically, chelators possess multiple functional groups, such as quaternary ammonium and amino groups, which can encapsulate metal ions within the molecule. This encapsulation reduces the catalytic performance of metal ions, thereby mitigating their influence on reactions.
Chelators are widely used in the fields of pharmaceutical preparations, cosmetics and food to regulate pH values and enhance stability.

Chelators (149):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-100545
    BAPTA-AM 126150-97-8 99.68%
    BAPTA-AM is a well-known membrane permeable Ca2+ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively.
    BAPTA-AM
  • HY-D0861
    EGTA 67-42-5 99.89%
    EGTA is a cell-impermeant specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages.
    EGTA
  • HY-Y0682
    Ethylenediaminetetraacetic acid 60-00-4 98.29%
    Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research.
    Ethylenediaminetetraacetic acid
  • HY-100168
    BAPTA 85233-19-8 98.10%
    BAPTA is a selective and cell-impermeant chelator for calcium. BAPTA has high selectivity against magnesium and calcium. BAPTA can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
    BAPTA
  • HY-W004544
    o-Phenanthroline 66-71-7 99.96%
    o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor.
    o-Phenanthroline
  • HY-W004563
    Neocuproine 484-11-7 99.97%
    Neocuproine is an organic compound commonly used as a complexing reagent and copper ion detector. It can form stable complexes with copper ions, and can play a catalytic role in certain chemical reactions and analytical methods. In addition, this compound is also widely used in some biomedical fields, such as in the study of copper metabolism disorders and neurodegenerative diseases
    Neocuproine
  • HY-W018746
    EDTA disodium 139-33-3 99.2%
    EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.
    EDTA disodium
  • HY-D0973
    EGTA-AM 99590-86-0 99.77%
    EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca2+ chelator with slow chelating dynamics.
    EGTA-AM
  • HY-D0180
    18-Crown-6-ether 17455-13-9 99.77%
    18-Crown-6-ether is a type of crown ether compound and a specific structure dissociating agent. 18-Crown-6-ether can compete with K+ for binding to G-quadruplexes, disrupting their stable structure to regulate the functions of related systems. 18-Crown-6-ether combines with K+ and other metal ions to achieve precise ion transmembrane transport. 18-Crown-6-ether can act as an "susceptibility substrate" for the multi-drug efflux pump EmrE (a bacterial multidrug resistance transporter), ultimately inhibiting bacterial growth. 18-Crown-6-ether can be used in microcapsule controlled release and the research on developing antibacterial enhancers.
    18-Crown-6-ether
  • HY-Y0262B
    Sodium oxalate,ACS,99.5% 62-76-0 99.65%
    Sodium oxalate is an orally active dispersant and coordination agent. Sodium oxalate causes mitochondrial dysfunction. Sodium oxalate has catalytic enhancing activity. Sodium oxalate induces stable chronic kidney disease. Sodium oxalate induces highly malignant and undifferentiated breast tumors.
    Sodium oxalate,ACS,99.5%
  • HY-B0812
    5-Sulfosalicylic acid dihydrate 5965-83-3 99.90%
    5-Sulfosalicylic acid dihydrate is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid dihydrate is effective against the breast cancer cell line, MCF-7, with less toxicity. 5-Sulfosalicylic acid dihydrate has antioxidant activities.
    5-Sulfosalicylic acid dihydrate
  • HY-W007451
    15-Crown-5 33100-27-5 99.81%
    15-Crown-5 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    15-Crown-5
  • HY-100168B
    BAPTA tetrapotassium 73630-08-7 99.45%
    BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA has high selectivity against magnesium and calcium. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
    BAPTA tetrapotassium
  • HY-W015236
    H-Gly-Gly-Gly-OH 556-33-2 99.70%
    H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.
    H-Gly-Gly-Gly-OH
  • HY-D0836
    EDTA dipotassium dihydrate 25102-12-9 99.17%
    EDTA dipotassium dihydrate is a metal ion chelator that forms stable and water-soluble chelates with a variety of metal ions. EDTA dipotassium is commonly used as a blood anticoagulant, which can effectively prevent blood coagulation and maintain the morphology and function of cells in blood samples. In the industrial field, EDTA dipotassium can be used to remove the adverse effects of metal ions and prevent oxidation and deterioration caused by metal ions.
    EDTA dipotassium dihydrate
  • HY-W009722
    Sodium diethylcarbamodithioate trihydrate 20624-25-3 98.0%
    Sodium diethylcarbamodithioate (Ditiocarb sodium) trihydrate is a copper reagent. The reaction with Cu2+ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer.
    Sodium diethylcarbamodithioate trihydrate
  • HY-W782083
    p-SCN-Bn-NOTA trihydrochloride 1583289-85-3 99.75%
    p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer.
    p-SCN-Bn-NOTA trihydrochloride
  • HY-158067
    Deferoxamine-DBCO 2359695-48-8
    Deferoxamine-DBCO is a bifunctional chelating agent. Deferoxamine-DBCO efficiently chelates with radioactive metals (such as 89Zr) through the DFO structure to achieve radiolabeling. Deferoxamine-DBCO undergoes a metal-free Huisgen cycloaddition reaction with azide-containing biomolecules (such as siRNA, monoclonal antibodies) under bioorthogonal conditions through the DBCO structure to achieve targeted coupling. Deferoxamine-DBCO has efficient metal chelating ability and specific bioorthogonal reaction activity. Deferoxamine-DBCO can be used for targeted radioactive imaging studies of tumors.
    Deferoxamine-DBCO
  • HY-W250574
    NOTA-bis(tBu)ester 1161415-28-6 98.0%
    NOTA-bis (tBu) ester is a derivative of NOTA (HY-134418). NOTA-bis (tBu) ester is radiolabeled with 68Ga to form ZD2-(68Ga-NOTA) after conjugation with ZD2. ZD2-(68Ga-NOTA) can be used for PET imaging studies of pancreatic cancer.
    NOTA-bis(tBu)ester
  • HY-131926
    EDTA (iron sodium) 15708-41-5
    EDTA iron sodium (NaFeEDTA; Sodium iron EDTA) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    EDTA (iron sodium)