GP-IX/CD42a
Glycoprotein IX (CD42a) is the smallest subunit of the GPIb-IX-V receptor complex, the platelet surface machinery that captures von Willebrand factor under high shear stress. Encoded by GP9, the chain associates non-covalently with GPIb alpha, GPIb beta and GPV, stabilizing the complex and contributing to its surface expression. Although GP-IX lacks a direct ligand-binding site, mutations in GP9 produce Bernard-Soulier syndrome, the macrothrombocytopenia caused by failure of the whole complex to reach the membrane. Anti-GP-IX antibodies have also been reported in immune-mediated thrombocytopenia. Recombinant GP-IX serves mainly as a component for reconstituting functional vWF-binding complexes.
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GP-IX/CD42a Recombinant Proteins (1)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
