SgK071

SgK071 is a placeholder designation from kinome-wide screens that corresponds to the human gene STKLD1, serine/threonine kinase like death domain 1. The protein is an understudied kinase with no firmly established substrates, and its domain organization places it outside the classical families. Published work, largely based on expression analysis and knockdown in cell lines, reports elevated STKLD1 levels in hepatocellular, gastric and other carcinomas, where silencing reduces proliferation and colony formation, and associations with cell-cycle progression and apoptosis have been proposed. These findings need independent confirmation, so recombinant STKLD1 is used mainly for antibody generation, biochemical characterization and screening campaigns.