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Cadherins are transmembrane cell-cell adhesion molecules conserved among metazoan organisms, which play essential roles in tissue morphogenesis and homeostasis. Cadherins constitute a large superfamily of cell adhesion molecules. Cadherins can be classified into four major subfamilies: 1) The classical cadherins, including type I classical cadherins such as E-cadherin, N-cadherin, and P-cadherin and type II classical cadherins such as VE-cadherin and OB-cadherin; 2) The desmosomal cadherins; 3) Protocadherins; and 4) atypical cadherins (Fat, Dachsous, and flamingo/CELSR). Nearly all cadherins are composed of three components: an extracellular cadherin domain (EC) responsible for homotypic cadherin-cadherin interaction; a single-pass transmembrane domain (absent in seven-pass transmembrane cadherins); and a cytoplasmic domain acts as a connector between cell surface and cytoskeleton.
The cadherins function in cell recognition, tissue morphogenesis and tumor suppression. The disruption of cadherin signaling has significant implications on tumor formation and progression. Altered cadherin expression plays a vital role in tumorigenesis, tumor progression, angiogenesis, and tumor immune response.
N-Cadherin Protein forms dimers with CDH2 chains, promoting cell-cell adhesion and sorting of cell types. It regulates neural stem cell quiescence by anchoring them to ependymocytes, disrupted by MMP24 cleavage. It also promotes cell-to-cell junctions and neurite branching, and regulates dendritic spine density. N-Cadherin Protein interacts with CDCP1, PCDH8, OBSCN, FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43, CTTN, and FBXO45. N-Cadherin Protein, Human (699a.a, HEK293, His) is the recombinant human-derived N-Cadherin protein, expressed by HEK293 , with C-His labeled tag. The total length of N-Cadherin Protein, Human (699a.a, HEK293, His) is 699 a.a., with molecular weight of 75-90 kDa.
The Cadherin-1/CD324 protein is a calcium-dependent cell adhesion protein that interacts with homology in junctional cells to facilitate cell type sorting. CDH1 is involved in regulating intercellular adhesion, mobility, and epithelial cell proliferation. Cadherin-1/CD324 Protein, Human (HEK293, Fc) is the recombinant human-derived Cadherin-1/CD324 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Cadherin-1/CD324 Protein, Human (HEK293, Fc) is 685 a.a., with molecular weight of 116-126 kDa.
DSG3 is a component of intercellular desmosome junctions and plays a key role in promoting intercellular adhesion by participating in important interactions with plaque proteins and intermediate filaments. Carefully orchestrated interactions between DSG3 and these structural elements are critical for maintaining the integrity and strength of cell-to-cell connections. DSG3 Protein, Human (Baculovirus, His) is the recombinant human-derived DSG3 protein, expressed by Sf9 insect cells , with C-6*His labeled tag. The total length of DSG3 Protein, Human (Baculovirus, His) is 566 a.a., with molecular weight of 67 kDa.
DSG-2 is an important component of intercellular desmosome junctions and actively participates in complex interactions between plaque proteins and intermediate filaments, thereby promoting strong intercellular adhesion. By binding to these structural components, DSG-2 helps maintain cell cohesion and tissue integrity. DSG-2/Desmoglein-2 Protein, Human (HEK293, His) is the recombinant human-derived DSG-2/Desmoglein-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DSG-2/Desmoglein-2 Protein, Human (HEK293, His) is 560 a.a., with molecular weight of 70-80 kDa.
Cadherin-1/CD324 Protein, Human (HEK293, His) is a recombinant human E-cadherin produced in HEK293 cells, with His tag. Cadherin-1/CD324/E-cadherin is one of the most important molecules in cell-cell adhesion in epithelial tissues.
The Cadherin-1/CD324 protein is a calcium-dependent cell adhesion protein that interacts with homology in junctional cells to facilitate cell type sorting. CDH1 is involved in regulating intercellular adhesion, mobility, and epithelial cell proliferation. Cadherin-1/CD324 Protein, Human (Biotinylated, HEK293, Fc) is the recombinant human-derived Cadherin-1/CD324 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Cadherin-1/CD324 Protein, Human (Biotinylated, HEK293, Fc) is 685 a.a., with molecular weight of ~87.1 KDa.
CDH16, a calcium-dependent cell adhesion protein, belongs to the cadherin family. It exhibits homophilic interactions, potentially contributing to cell-type sorting and regulating cell-cell adhesions for cellular organization. CDH16 Protein, Human (HEK293, His) is the recombinant human-derived CDH16 protein, expressed by HEK293 , with C-His labeled tag. The total length of CDH16 Protein, Human (HEK293, His) is 768 a.a., with molecular weight of 90-110 kDa.
Cadherin-17 Protein, Human (765a.a, HEK293, His) is a recombinant human Cadherin-17 produced in HEK293 cells, with His tag. Cadherin-17 is a calcium-dependent transmembrane glycoprotein that mediates cell-cell adhesion in intestinal epithelium.
Cadherin-3 protein, a calcium-dependent adhesion molecule, facilitates cell interactions. It prefers homophilic interaction with other cadherin-3 proteins, aiding cell connection. This interaction helps sort and organize cell types. Cadherin-3 also interacts with CDCP1 and CTNNB1, impacting cellular processes. Cadherin-3 Protein, Human (547a.a, HEK293, His) is the recombinant human-derived Cadherin-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-3 Protein, Human (547a.a, HEK293, His) is 547 a.a., with molecular weight of 70-80 kDa.
Cadherin-9 Protein, a calcium-dependent cell adhesion molecule, functions within cellular interactions. Exhibiting calcium-dependent adhesion, CDH9 prefers homophilic interactions, connecting cells. This unique feature suggests a potential role in sorting heterogeneous cell types. The calcium-dependent mechanism underscores cadherins' regulatory role in cellular cohesion within intercellular junctions, maintaining tissue integrity and function. Cadherin-3 Protein, Cynomolgus (547a.a, HEK293, His) is the recombinant cynomolgus-derived Cadherin-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-3 Protein, Cynomolgus (547a.a, HEK293, His) is 547 a.a., with molecular weight of 70-80 kDa.
DSG3 protein facilitates cell-cell adhesion by mediating the interaction between plaque proteins and intermediate filaments at intercellular desmosome junctions. It interacts with PKP2, enhancing the stability and integrity of these junctions. DSG3 plays a vital role in maintaining tissue architecture and structural integrity through strong cell adhesion. DSG3 Protein, Mouse (His-SUMO) is the recombinant mouse-derived DSG3 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of DSG3 Protein, Mouse (His-SUMO) is 568 a.a., with molecular weight of ~79.2 kDa.
Cadherin-13 proteins are calcium-dependent cell adhesion molecules that exhibit a preference for homogeneous interactions, promote connections between adjacent cells, and may play a role in cell type sorting. Cadherin-13 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Cadherin-13 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-13 Protein, Mouse (HEK293, His) is 692 a.a., with molecular weight of 90-110 kDa.
Cadherin family member 2; CDHF2; DSC3; Desmosomal glycoprotein II
Human
HEK293
DSC2/Desmocollin-2 protein is vital for intercellular desmosome junctions, mediating adhesion by interacting with plaque proteins and intermediate filaments. It also regulates cell positioning and interacts with DSP, PKP2, and JUP, strengthening junction stability. Overall, DSC2/Desmocollin-2 protein maintains tissue organization and functionality. DSC2/Desmocollin-2 Protein, Human (HEK293, His) is the recombinant human-derived DSC2/Desmocollin-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DSC2/Desmocollin-2 Protein, Human (HEK293, His) is 657 a.a., with molecular weight of ~85 & 100 KDa, respectively.
rHuCadherin-11, His; Cadherin 11 Type 2 OB-cadherin (Osteoblast); CDH11; Cadherin-11
Human
HEK293
Cadherin-11 Protein, Human (HEK293, His) is a recombinant human Cadherin-11 produced in HEK293 cells, with His tag. Cadherin-11 is a classical cadherin adhesion molecule that mediates homophilic cell-to-cell adhesion.
Cadherin-3 Protein, Human (630a.a, HEK293, His) is a recombinant human Cadherin-3 (P-cadherin) produced in HEK293 cells, with His tag. Cadherin-3 is a classical cell-to-cell adhesion molecule with a homeostatic function in several normal tissues.
DSG-2/Desmoglein-2 proteins mediate cell-cell adhesion by interacting with plaque proteins and intermediate filaments at desmosome junctions. It plays a vital role in desmosome structure, maintaining tissue integrity and cohesion. DSG-2/Desmoglein-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DSG-2/Desmoglein-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DSG-2/Desmoglein-2 Protein, Mouse (HEK293, His) is 564 a.a., with molecular weight of 75-80 kDa.
DSG3 protein facilitates cell-cell adhesion by mediating the interaction between plaque proteins and intermediate filaments at intercellular desmosome junctions. It interacts with PKP2, enhancing the stability and integrity of these junctions. DSG3 plays a vital role in maintaining tissue architecture and structural integrity through strong cell adhesion. DSG3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DSG3 protein, expressed by HEK293 , with C-His labeled tag. The total length of DSG3 Protein, Mouse (HEK293, His) is 568 a.a., with molecular weight of 68-78 kDa.
Cadherin-3 protein mediates cell-cell interactions by selectively binding to other cadherin molecules in a homophilic manner. This promotes adhesion between cells, aiding in the sorting and organization of different cell types. Cadherin-3 also interacts with CDCP1 and CTNNB1, regulating cellular processes and signaling pathways. Cadherin-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Cadherin-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-3 Protein, Mouse (HEK293, His) is 548 a.a., with molecular weight of 70-80 kDa.
