Cadherins
Cadherins are transmembrane cell-cell adhesion molecules conserved among metazoan organisms, which play essential roles in tissue morphogenesis and homeostasis. Cadherins constitute a large superfamily of cell adhesion molecules. Cadherins can be classified into four major subfamilies: 1) The classical cadherins, including type I classical cadherins such as E-cadherin, N-cadherin, and P-cadherin and type II classical cadherins such as VE-cadherin and OB-cadherin; 2) The desmosomal cadherins; 3) Protocadherins; and 4) atypical cadherins (Fat, Dachsous, and flamingo/CELSR). Nearly all cadherins are composed of three components: an extracellular cadherin domain (EC) responsible for homotypic cadherin-cadherin interaction; a single-pass transmembrane domain (absent in seven-pass transmembrane cadherins); and a cytoplasmic domain acts as a connector between cell surface and cytoskeleton. The cadherins function in cell recognition, tissue morphogenesis and tumor suppression. The disruption of cadherin signaling has significant implications on tumor formation and progression. Altered cadherin expression plays a vital role in tumorigenesis, tumor progression, angiogenesis, and tumor immune response.
- LI-Cadherin/Cadherin-17 (18)
- E-Cadherin/Cadherin-1 (7)
- P-Cadherin/Cadherin-3 (7)
- K-Cadherin/Cadherin-6 (7)
- Cadherin-13 (5)
- DSG3 (4)
- Desmocollin-2 (4)
- Cadherin-5 (3)
- Cadherin-8 (3)
- N-Cadherin (2)
- Cadherin-11 (2)
- Cadherin-16 (2)
- DSG2 (2)
- Cadherin-9 (1)
- Cadherin-10 (1)
- Cadherin-12 (1)
- Cadherin-18 (1)
- Cadherin-19 (1)
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Cadherins Recombinant Proteins (72)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
