2. Recombinant Proteins
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Cadherins

Cadherins

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Cadherins are transmembrane cell-cell adhesion molecules conserved among metazoan organisms, which play essential roles in tissue morphogenesis and homeostasis. Cadherins constitute a large superfamily of cell adhesion molecules. Cadherins can be classified into four major subfamilies: 1) The classical cadherins, including type I classical cadherins such as E-cadherin, N-cadherin, and P-cadherin and type II classical cadherins such as VE-cadherin and OB-cadherin; 2) The desmosomal cadherins; 3) Protocadherins; and 4) atypical cadherins (Fat, Dachsous, and flamingo/CELSR). Nearly all cadherins are composed of three components: an extracellular cadherin domain (EC) responsible for homotypic cadherin-cadherin interaction; a single-pass transmembrane domain (absent in seven-pass transmembrane cadherins); and a cytoplasmic domain acts as a connector between cell surface and cytoskeleton. The cadherins function in cell recognition, tissue morphogenesis and tumor suppression. The disruption of cadherin signaling has significant implications on tumor formation and progression. Altered cadherin expression plays a vital role in tumorigenesis, tumor progression, angiogenesis, and tumor immune response.

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