DSG2
DSG2, or desmoglein-2, is the only desmoglein expressed in all desmosome-bearing tissues, including cardiac muscle, where it is indispensable for intercalated disc integrity. Through calcium-dependent homophilic bonds with other desmosomal cadherins, it couples keratin and desmin intermediate filaments to cell-cell contacts via plakoglobin and desmoplakin. Mutations in DSG2 are a leading cause of arrhythmogenic cardiomyopathy, an inherited disorder of fibrofatty replacement of the myocardium with life-threatening ventricular arrhythmias. Beyond the heart, DSG2 is frequently overexpressed in carcinomas, where it supports proliferation and invasion, making it both a genetic disease gene and an antibody-target candidate.
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DSG2 Recombinant Proteins (2)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
