DSG2/Desmoglein-2 Protein, Mouse (HEK293, His)

DSG2/Desmoglein-2 proteins mediate cell-cell adhesion by interacting with plaque proteins and intermediate filaments at desmosome junctions. It plays a vital role in desmosome structure, maintaining tissue integrity and cohesion. DSG2/Desmoglein-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DSG2/Desmoglein-2 protein, expressed by HEK293 , with C-His labeled tag.

DSG-2, a key constituent of intercellular desmosome junctions, plays a pivotal role in mediating cell-cell adhesion by participating in the interaction between plaque proteins and intermediate filaments. This integral involvement in desmosomal structures underscores its significance in maintaining tissue integrity and cohesion. Notably, DSG-2 forms essential connections within the desmosome complex, contributing to the robustness of intercellular adhesion. Furthermore, its interaction with PKP2 further emphasizes the intricate molecular network that orchestrates the stability and functionality of desmosomes in cellular junctions.

Mouse

HEK293

C-8*His

O55111 (A55-A618)

13511  [NCBI]

Extracellular Domain

AWITAPVALREGEDLSRKNPIAKIHSDLAEEKGIKITYKYTGKGITEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLEKPLELRIKVLDINDNEPVFTQEVFVGSIEELSAAHTLVMKITATDADDPETLNAKVSYRIVSQEPANSHMFYLNKDTGEIYTTSFTLDREEHSSYSLTVEARDGNGQITDKPVQQAQVQIRILDVNDNIPVVENKMYEGTVEENQVNVEVMRIKVTDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVTLVKEVDYEEMKKLDLSIIVTNKAAFHKSILSKYKATPIPITVKVKNVVEGIHFKSSVVSFRASEAMDRSSLSRSIGNFQVFDEDTGQAAKVTYVKVQDTDNWVSVDSVTSEIKLVKIPDFESRYVQNGTYTAKVVAISKEHPQKTITGTIVITVEDVNDNCPVLVDSVRSVCEDEPYVNVTAEDLDGAQNSAPFSFSIIDQPPGTAQKWKITHQESTSVLLQQSERKRGRSEIPFLISDSQGFSCPERQVLQLTVCECLKGGGCVAAQYDNYVGLGPA

75-80 kDa

≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.