DSG2/Desmoglein-2 Protein, Mouse (HEK293, His)
Based on 1 Customer Validation
DSG2/Desmoglein-2 proteins mediate cell-cell adhesion by interacting with plaque proteins and intermediate filaments at desmosome junctions. It plays a vital role in desmosome structure, maintaining tissue integrity and cohesion. DSG2/Desmoglein-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DSG2/Desmoglein-2 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
DSG2/Desmoglein-2 proteins mediate cell-cell adhesion by interacting with plaque proteins and intermediate filaments at desmosome junctions. It plays a vital role in desmosome structure, maintaining tissue integrity and cohesion. DSG2/Desmoglein-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DSG2/Desmoglein-2 protein, expressed by HEK293 , with C-His labeled tag.
Background
DSG-2, a key constituent of intercellular desmosome junctions, plays a pivotal role in mediating cell-cell adhesion by participating in the interaction between plaque proteins and intermediate filaments. This integral involvement in desmosomal structures underscores its significance in maintaining tissue integrity and cohesion. Notably, DSG-2 forms essential connections within the desmosome complex, contributing to the robustness of intercellular adhesion. Furthermore, its interaction with PKP2 further emphasizes the intricate molecular network that orchestrates the stability and functionality of desmosomes in cellular junctions.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-8*His
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Accession
O55111 (A55-A618)
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Molecular Construction
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N-term
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DSG2 (A55-A618)
Accession # O55111 -
8*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
DSG2; Cadherin Family Member 5; Desmoglein 2; Desmoglein-2; CDHF5; HDGC
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AA Sequence
AWITAPVALREGEDLSRKNPIAKIHSDLAEEKGIKITYKYTGKGITEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLEKPLELRIKVLDINDNEPVFTQEVFVGSIEELSAAHTLVMKITATDADDPETLNAKVSYRIVSQEPANSHMFYLNKDTGEIYTTSFTLDREEHSSYSLTVEARDGNGQITDKPVQQAQVQIRILDVNDNIPVVENKMYEGTVEENQVNVEVMRIKVTDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVTLVKEVDYEEMKKLDLSIIVTNKAAFHKSILSKYKATPIPITVKVKNVVEGIHFKSSVVSFRASEAMDRSSLSRSIGNFQVFDEDTGQAAKVTYVKVQDTDNWVSVDSVTSEIKLVKIPDFESRYVQNGTYTAKVVAISKEHPQKTITGTIVITVEDVNDNCPVLVDSVRSVCEDEPYVNVTAEDLDGAQNSAPFSFSIIDQPPGTAQKWKITHQESTSVLLQQSERKRGRSEIPFLISDSQGFSCPERQVLQLTVCECLKGGGCVAAQYDNYVGLGPA
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Predicted Molecular Mass
63.7 kDa
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Molecular Weight
Approximately 75-80 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (238 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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