1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine 2, 3-dioxygenase (IDO) is an intracellular enzyme that catalyzes the transformation of L-tryptophan to N-formylkynurenine, which is the first and rate-controlling step in the kynurenine pathway.

IDO is a rate-limiting enzyme that catalyzes the degradation of tryptophan into kynurenine and is recognized to exert a tolerizing effect on T cells that require tryptophan to proliferate5. IDO also plays an important role in the activation and regulation of functionally quiescent regulatory T cells.

IDO is a heme-containing enzyme that catalyzes the oxidative cleavage of 2,3 double bond of indole ring. IDO has the ability to inhibit T-cell activation by tryptophan starvation, whereas T-cell survival and proliferation are regulated by O2 free radicals and kynurenine derivatives. IDO plays a crucial role in autoimmunity,infections and malignancies.

Indoleamine-2,3-dioxygenase (IDO) one of the most important immunoregulator enzyme responsible for metabolism of tryptophan as part of Kynurenin pathway. Tryptophan is catabolized in the tumor tissue by the rate-limiting enzyme IDO expressed in tumor cells or antigen presenting cells.

Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

  • IDO1

  • IDO2

  • IDO

Indoleamine 2,3-Dioxygenase (IDO) Related Products (28):

Cat. No. Product Name Effect Purity
  • HY-15760
    Necrostatin-1 Inhibitor 99.20%
    Necrostatin-1 (Nec-1) is a potent, selective and cell-permeable necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 acts by inhibiting (RIP1) kinase domain in the necroptosis pathway.
  • HY-15689
    Epacadostat Inhibitor 99.65%
    Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM.
  • HY-101560
    Linrodostat Inhibitor 99.92%
    Linrodostat (BMS-986205; ONO-7701) is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
  • HY-16724
    Indoximod Inhibitor 98.98%
    Indoximod (D-1MT, NLG8189) is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki of 19 μM.
  • HY-13983
    IDO-IN-7 Inhibitor 99.92%
    IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC50 of 38 nM.
  • HY-112147
    IDO1 and HDAC1 Inhibitor Inhibitor
    IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC50s of 69.0 nM and 66.5 nM, respectively.
  • HY-128355
    IDO/TDO-IN-1 Inhibitor
    IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively .
  • HY-N0430A
    Coptisine Sulfate Inhibitor
    Coptisine Sulfate is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.
  • HY-18770B
    Navoximod Inhibitor 99.99%
    Navoximod (GDC-0919; NLG-​919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.
  • HY-N0736
    Coptisine chloride Inhibitor 99.29%
    Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.
  • HY-101111
    PF-06840003 Inhibitor 99.80%
    PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor.
  • HY-18769
    IDO-IN-4 Inhibitor 99.40%
    IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.
  • HY-112164
    IACS-8968 Inhibitor 98.13%
    IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.
  • HY-100687
    GNF-PF-3777 Inhibitor
    GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
  • HY-15683
    IDO5L Inhibitor 99.89%
    IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM.
  • HY-100771
    IDO-IN-2 Inhibitor 98.54%
    IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1, has IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell.
  • HY-18770
    IDO-IN-5 Inhibitor 99.90%
    IDO-IN-5 (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC50 of 1-10 μM.
  • HY-18770C
    IDO-IN-8 Inhibitor 99.99%
    IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM.
  • HY-111540
    LY-3381916 Inhibitor
    LY-3381916 is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
  • HY-16987
    IDO-IN-3 Inhibitor 99.88%
    IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.