1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Inhibitory Checkpoint Molecules
  4. IDO

Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme which catalyzes the initial and rate limiting step in the degradation pathway of the essential amino acid tryptophan and is expressed in professional APCs, epithelial cells, vascular endothelium and tumor cells. IDO is an important enzyme in both cancer development and cancer progression. It supports inflammation in the tumor microenvironment, development of immune tolerance to tumor antigens in stromal and immune cells, suppression of T and natural killer (NK) cells, generation and activation of T regulatory cells (Tregs) and myeloid-derived suppressor cells, and promotion of tumor angiogenesis. It is reported that functionally active IDO protein is expressed in a wide variety of human hematologic malignancies, such as acute monocytic leukemia, acute lymphocytic leukemia, acute myeloid leukemia and T-cell leukemia/lymphoma, and solid tumors, such as breast cancer, colorectal cancer, endometrial cancer, gastric cancer, glioblastoma, gynecological cancers, head and neck cancers, non-small cell lung cancer (NSCLC), melanoma, and pancreatic cancer. As an immune checkpoint pathway, the IDO pathway is emerging as an important modality for the treatment of cancer.

Cat. No. Product Name / Synonyms Species Source
  • HY-P70679
    IDO Protein, Human (His)

    Indole 2; 3-dioxygenase; Indoleamine 2; 3-dioxygenase 1; IDO-1; IDO1; IDO; INDO

    Human E. coli
    IDO proteins catalyze the first step in tryptophan catabolism via the kynurenine pathway, which is critical for immune tolerance and homeostasis maintenance. IDO Protein, Human (His) is the recombinant human-derived IDO protein, expressed by E. coli , with N-6*His labeled tag. The total length of IDO Protein, Human (His) is 403 a.a., with molecular weight of 40-50 kDa.
  • HY-P72616
    IDO Protein, Mouse (His)

    Indoleamine 2,3-dioxygenase 1; IDO-1; Indoleamine-pyrrole 2,3-dioxygenase; IDO; INDO

    Mouse E. coli
    IDO Protein, an enzyme, is involved in the metabolism of tryptophan. Dysregulation of IDO Protein has been linked to immune escape mechanisms and tumor progression. Targeting IDO Protein may provide potential therapeutic interventions in cancer by modulating tryptophan metabolism, enhancing immune responses, and inhibiting tumor growth. IDO Protein, Mouse (His) is the recombinant mouse-derived IDO protein, expressed by E. coli , with N-6*His labeled tag. The total length of IDO Protein, Mouse (His) is 407 a.a., with molecular weight of 40-50 kDa.
  • HY-P73121
    IDO Protein, Human

    Indoleamine 2; 3-dioxygenase 1; IDO-1; IDO1; IDO; INDO

    Human E. coli
    IDO proteins catalyze the first step in tryptophan catabolism via the kynurenine pathway, which is critical for immune tolerance and homeostasis maintenance. IDO Protein, Human is the recombinant human-derived IDO protein, expressed by E. coli , with tag free. The total length of IDO Protein, Human is 402 a.a., with molecular weight of ~46 kDa.
Cat. No. Product Name Effect Purity