2. Recombinant Proteins
  3. Fc Receptors
  4. FcRn

FcRn

FcRn

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The FcRn receptor (neonatal Fc receptor) was initially identified as an immunoglobulin G (IgG) receptor in the intestinal epithelial cells of neonatal rodents, which transports IgG from the maternal milk across the mucosal layer and releases it into blood of neonatal rodents to endow passive immunity. In humans, passive immunity is delivered via the placenta, but FcRn is expressed in the intestine and is maintained throughout adult life that contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. FcRn, as an atypical FcγR, is structurally related to MHC-I molecules with a 40 kDa alpha (α) heavy chain that non-covalently associates with the 12 kDa light chain β2m. FcRn has a quasi-ubiquitous expression pattern, possesses a predominantly intracellular localization, is monomorphic, and binds another, structurally and functionally unrelated protein to IgG.

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