1. Recombinant Proteins
  2. Fc Receptors
  3. FcRn

The FcRn receptor (neonatal Fc receptor) was initially identified as an immunoglobulin G (IgG) receptor in the intestinal epithelial cells of neonatal rodents, which transports IgG from the maternal milk across the mucosal layer and releases it into blood of neonatal rodents to endow passive immunity. In humans, passive immunity is delivered via the placenta, but FcRn is expressed in the intestine and is maintained throughout adult life that contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. FcRn, as an atypical FcγR, is structurally related to MHC-I molecules with a 40 kDa alpha (α) heavy chain that non-covalently associates with the 12 kDa light chain β2m. FcRn has a quasi-ubiquitous expression pattern, possesses a predominantly intracellular localization, is monomorphic, and binds another, structurally and functionally unrelated protein to IgG.

Cat. No. Product Name / Synonyms Species Source
  • HY-P73522
    FCGRT-B2M Heterodimer Protein, Human (HEK293, His)

    FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin

    Human HEK293
    The FCGRT protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. It binds IgG at the intestinal epithelium and forms an FcRn-IgG complex that is transcytosed across the epithelium, releasing IgG into the blood or tissue. FCGRT-B2M Heterodimer Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Human (HEK293, His), has molecular weight of ~35 & 12 kDa, respectively.
  • HY-P76920
    FCGRT-B2M Heterodimer Protein, Cynomolgus (HEK293, His)

    FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin

    Cynomolgus HEK293
    The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus (HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus (HEK293, His), has molecular weight of ~35 & 12 kDa, respectively.
  • HY-P70601
    FCRN-B2M Protein, Human (HEK293, His)

    IgG receptor FcRn; Neonatal Fc receptor; FCRN

    Human HEK293
    FCGRT is an IgG Fc receptor. Fc receptor expression is up-regulated by pro-inflammatory cytokines TNF and down-regulated by IFN-γ. FCGRT plays a role in regulating IgG and serum albumin conversion. Overexpression of FCGRT is also associated with poor prognosis of tumors. FCRN-B2M Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FCRN-B2M protein, expressed by HEK293 , with C-6*His labeled tag. FCRN-B2M Protein, Human (HEK293, His), has molecular weight of ~32 & 12 kDa, respectively.
  • HY-P70656
    FCRN Protein, Mouse (HEK293, His)

    IgG receptor FcRn; Neonatal Fc receptor; FCRN

    Mouse HEK293
    The FCRN protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. FCRN Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived FCRN protein, expressed by HEK293 , with C-6*His labeled tag. FCRN Protein, Mouse (HEK293, His), has molecular weight of 42-58 & 12 kDa, respectively.
  • HY-P72192
    FCGRT Protein, Human (GST)

    Alpha chain; Fc fragment of IgG; receptor transporter; alpha; FCGRN_HUMAN; FCGRT; FcRn alpha chain; FcRn; FCRN; alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor; intestinal; heavy chain; Neonatal Fc receptor

    Human E. coli
    The FCGRT protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. It binds IgG at the intestinal epithelium and forms an FcRn-IgG complex that is transcytosed across the epithelium, releasing IgG into the blood or tissue. FCGRT Protein, Human (GST) is the recombinant human-derived FCGRT protein, expressed by E. coli , with N-GST labeled tag. The total length of FCGRT Protein, Human (GST) is 274 a.a., with molecular weight of ~57.4 kDa.
  • HY-P72368
    FCRN-B2M Protein, Human (Biotinylated, HEK293, His-Avi)

    IgG receptor FcRn; Neonatal Fc receptor; FCRN

    Human HEK293
    FCGRT is an IgG Fc receptor. Fc receptor expression is up-regulated by pro-inflammatory cytokines TNF and down-regulated by IFN-γ. FCGRT plays a role in regulating IgG and serum albumin conversion. Overexpression of FCGRT is also associated with poor prognosis of tumors. FCRN-B2M Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived FCRN-B2M protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. FCRN-B2M Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 35 & 13 kDa, respectively.
  • HY-P75760
    FCGRT-B2M Heterodimer Protein, Rat (HEK293, His, solution)

    FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin

    Rat HEK293
    The FCGRT-B2M heterodimeric protein is a cell surface receptor that interacts with IgG and albumin and contributes to effective humoral immunity. FCGRT-B2M Heterodimer Protein, Rat (HEK293, His, solution) is a recombinant protein dimer complex containing rat-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Rat (HEK293, His, solution), has molecular weight of ~35 & 12 kDa, respectively.
  • HY-P75760A
    FCGRT-B2M Heterodimer Protein, Rat (HEK293, C-His)

    FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin

    Rat HEK293
    The FCGRT-B2M heterodimeric protein is a cell surface receptor that interacts with IgG and albumin and contributes to effective humoral immunity. FCGRT-B2M Heterodimer Protein, Rat (HEK293, C-His) is a recombinant protein dimer complex containing rat-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Rat (HEK293, C-His), has molecular weight of ~38-55 & 12 kDa, respectively.
  • HY-P75199
    FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi)

    FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin

    Mouse HEK293
    The FCRN protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing mouse-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-Avi, C-His labeled tag. FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi), has molecular weight of ~46 kDa.
  • HY-P76919
    FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, His-Avi)

    FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin

    Cynomolgus HEK293
    The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, His-Avi) is a recombinant protein dimer complex containing cynomolgus-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-Avi, C-His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, His-Avi), has molecular weight of ~33.7 & 11.6 KDa, respectively.
  • HY-P76921
    FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, HEK293, His)

    FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin

    Cynomolgus HEK293
    The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, HEK293, His), has molecular weight of ~31.9 & 11.6 KDa, respectively.
  • HY-P701255
    FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His)

    FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M

    Human HEK293
    The FCGRT protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. It binds IgG at the intestinal epithelium and forms an FcRn-IgG complex that is transcytosed across the epithelium, releasing IgG into the blood or tissue. FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing human-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with Strep, His labeled tag. FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His), has molecular weight of ~33 kDa(FCGRT) & 13 kDa(B2M), respectively.
  • HY-P71664
    FCGRT Protein, Human (HEK293, His)

    Alpha chain; Fc fragment of IgG; receptor transporter; alpha; FCGRN_HUMAN; FCGRT; FcRn alpha chain; FcRn; FCRNNeonatal Fc receptor

    Human HEK293
    The FCGRT protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. It binds IgG at the intestinal epithelium and forms an FcRn-IgG complex that is transcytosed across the epithelium, releasing IgG into the blood or tissue. FCGRT Protein, Human (HEK293, His) is the recombinant human-derived FCGRT protein, expressed by HEK293 , with N-His labeled tag. The total length of FCGRT Protein, Human (HEK293, His) is 274 a.a., with molecular weight of ~34.4 kDa.
  • HY-P75200
    FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, HEK293, His)

    FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin

    Mouse HEK293
    The FCRN protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing mouse-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, HEK293, His), has molecular weight of ~44.2 kDa.
  • HY-P77665
    FCGRT-B2M Heterodimer Protein, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His)

    FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M

    Cynomolgus; Rhesus Macaque HEK293
    The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His) is a recombinant protein dimer complex containing cynomolgus, Rhesus Macaque-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His), has molecular weight of 35-38 kDa.
  • HY-P77667
    FCGRT-B2M Heterodimer Protein, Mouse (HEK293, His)

    FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M

    Mouse HEK293
    The FCRN protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. FCGRT-B2M Heterodimer Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Mouse (HEK293, His), has molecular weight of 50-55 kDa.
  • HY-P70881
    FCGRT-B2M Heterodimer Protein, Cynomolgus (HEK293, Flag-His)

    Beta-2-Microglobulin; B2M

    Cynomolgus HEK293
    The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus (HEK293, Flag-His) is a recombinant protein dimer complex containing cynomolgus-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-Flag, C-6*His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus (HEK293, Flag-His), has molecular weight of 33 & 14 kDa, respectively.
  • HY-P75761
    FCGRT-B2M Heterodimer Protein, Rat (Biotinylated, HEK293, His)

    FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin

    Rat HEK293
    The FCGRT-B2M heterodimeric protein is a cell surface receptor that interacts with IgG and albumin and contributes to effective humoral immunity. FCGRT-B2M Heterodimer Protein, Rat (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing rat-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Rat (Biotinylated, HEK293, His), has molecular weight of ~44 kDa.
Cat. No. Product Name Effect Purity