Fc alpha RI/CD89
Fc alpha receptor I, designated CD89, is the transmembrane receptor for IgA expressed on myeloid cells, including monocytes, macrophages, neutrophils, eosinophils and Kupffer cells. Two extracellular immunoglobulin-like domains bind both IgA1 and IgA2 subclasses, and activating signals are transduced by the associated Fc common gamma chain bearing an ITAM. Engagement by IgA-coated bacteria or immune complexes triggers phagocytosis, oxidative burst and inflammatory cytokine release, making the receptor central to mucosal immune defense. In IgA nephropathy, aberrant IgA-CD89 complexes shed from myeloid cells deposit in the kidney mesangium and drive glomerular inflammation.
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Fc alpha RI/CD89 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
