FCAR/CD89 Protein, Rat (HEK293, His)

FCAR is an Fc fragment of the IgA receptor, also known as CD89. Fcars are found on the cell surface of myeloid cells, including neutrophils, monocytes, macrophages, and eosinophils. FCAR exerts proinflammatory effects by participating in PI3K and PLC-γ signaling. FCAR is also an important Fc receptor for neutrophils to kill tumor cells. FCAR/CD89 Protein, Rat (HEK293, His) is the recombinant rat-derived FCAR/CD89 protein, expressed by HEK293 , with C-His labeled tag. The total length of FCAR/CD89 Protein, Rat (HEK293, His) is 207 a.a., with molecular weight of 35-40 kDa.

The Fc fragment of the IgA receptor (FCAR) encodes the transmembrane receptor FC-α RI, also known as CD89. Fcars are found on the cell surface of myeloid cells, including neutrophils, monocytes, macrophages, and eosinophils. FCAR plays a role in both pro-inflammatory and anti-inflammatory responses, depending on its binding status to IgA. FCAR exerts proinflammatory effects by participating in PI3K and PLC-γ signaling. FCAR is also an important Fc receptor for neutrophils to kill tumor cells^[1][2].

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Rat FCAR at 1 µg/mL can bind Rat IgA with an apparent KD is 5.683 nM.

Rat

HEK293

C-His

D3ZRL6/NP_973721.1 (Q22-N228)

365183  [NCBI]

35-40 kDa

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.