1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme

E1/E2/E3 Enzyme

Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.

E1/E2/E3 Enzyme Related Products (12):

Cat. No. Product Name Effect Purity
  • HY-N0077
    Ginkgolic Acid Inhibitor 99.59%
    Ginkgolic Acid is a natural compound with suspected cytotoxic, allergenic, mutagenic and carcinogenic properties, and it can inhibit protein SUMOylation both in vitro and in vivo without affecting in vivo ubiquitination.
  • HY-13296
    PYR-41 Inhibitor >98.0%
    PYR-41 is a specific and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 μM, with no or little activity at E2.
  • HY-100237
    SZL P1-41 Inhibitor 99.53%
    SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes.
  • HY-100507
    CC122 Agonist 99.37%
    CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity.
  • HY-103236
    NSC232003 Inhibitor 98.09%
    NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level.
  • HY-101488
    CC-885 Modulator
    CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity.
  • HY-19817
    PRT4165 Inhibitor >98.0%
    PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation.
  • HY-16661
    Skp2 Inhibitor C1 Inhibitor 98.80%
    Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.
  • HY-15301
    CC0651 Inhibitor 99.30%
    CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently (IC50=1.72 μM) inhibits the ubiquitination of p27Kip1, as confirmed by dose-response analysis.
  • HY-18643
    TZ9 Inhibitor 99.17%
    TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM.
  • HY-101836
    DKM 2-93 Inhibitor 98.87%
    DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM.
  • HY-13297
    PYZD-4409 Inhibitor >98.0%
    PYZD-4409 is a novel small molecule inhibitor of Ubiquitin-activating enzyme UBA1/E1 enzyme with an IC50 of 20 uM (cell-free enzymatic assay).
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.