1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme

E1/E2/E3 Enzyme

Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.

E1/E2/E3 Enzyme Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-13296
    PYR-41 Inhibitor >98.0%
    PYR-41 is a specific and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 uM, with no or little activity at E2.
  • HY-100507
    CC122 Agonist 99.37%
    CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity.CC-122 binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL.
  • HY-15301
    CC0651 Inhibitor 99.30%
    CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
  • HY-19817
    PRT4165 Inhibitor >98.0%
    PRT4165 is a potent inhibitor of PRC1 (Polycomb-repressive complex 1)-mediated H2A ubiquitylation.
  • HY-18643
    TZ9 Inhibitor
    TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM.
  • HY-101836
    DKM 2-93 Inhibitor 98.87%
    DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM.
  • HY-13297
    PYZD-4409 Inhibitor 98.51%
    PYZD-4409 is a novel small molecule inhibitor of Ubiquitin-activating enzyme UBA1/E1 enzyme with an IC50 of 20 uM (cell-free enzymatic assay).