1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. Subasumstat

Subasumstat (Synonyms: TAK-981)

Cat. No.: HY-111789 Purity: 98.56%
Handling Instructions

Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.

For research use only. We do not sell to patients.

Subasumstat Chemical Structure

Subasumstat Chemical Structure

CAS No. : 1858276-04-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 254 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 254 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 310 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities[1][2].

IC50 & Target

SUMOylation[1].

In Vitro

Subasumstat (TAK-981) is able to increase the production of type 1 IFN, thereby increasing type 1 IFN-mediated signaling, activating innate effector cells and enhancing the antitumor innate immune responses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A single sub-cutaneous injection of Subasumstat (TAK-981) in naive Balb/c mice at the brachial lymph nodes induces activation of DCs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

578.10

Formula

C₂₅H₂₈ClN₅O₅S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 75 mg/mL (129.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7298 mL 8.6490 mL 17.2980 mL
5 mM 0.3460 mL 1.7298 mL 3.4596 mL
10 mM 0.1730 mL 0.8649 mL 1.7298 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 7.5 mg/mL (12.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.56%

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Product Name:
Subasumstat
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HY-111789
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