2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-36

IL-36

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IL-36 consists of three subforms (IL-36α, IL-36β, IL-36γ), and belongs to IL-1 superfamily. IL-36 is normally expressed at low levels. Upon stimulation, they are inducted and act on a variety of cells including epithelial and immune cells. IL-36 mediates inflammatory response, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases, such as cathepsin G, elastase and proteinase-3[1].
IL-36 alpha binds to IL-36R and activates NF-κB and MAPK signaling pathways, thereby mediating inflammatory response[1]. IL-36 alpha is expressed in monocytes, T/B-lymphocytes, spleen, bone-marrow tonsils, lymph nodes and skin[2]. L-36 beta or IL-36 gamma binds to IL-36R and recruits the co-receptor IL-1RAcP, So that heterodimeric signaling complex brings Toll/IL-1R (TIR) domains of the 2 receptor chains in close proximity, and thereby activating NF-κB and MAPK signaling pathways[3]. IL-36 beta is expressed in monocytes, T/B-lymphocytes, bone-marrow, tonsils, heart, lung, testis, colon, neuron cells, glial cells[2]. IL-36 gamma is expressed in peripheral blood lymphocytes, keratinocytes, bronchial epithelial cells and THP-1 cells[2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70670
    IL-36 gamma/IL-1F9 Protein, Human (152a.a)

    IL-36 gamma; IL-36γ; Interleukin-36 gamma; IL36G; IL-1-related protein 2; IL-1RP2; IL-1 epsilon; IL-1F9; Interleukin-1 homolog 1; IL-1H1

    		Human E. coli
    IL-36 gamma (IL-1F9), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 gamma mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 gamma/IL-1F9 Protein, Human (152a.a) is a recombinant human IL-36 gamma (S18-D169) without any tag, which is produced in E. coli.
  • HY-P70702
    IL-36 alpha/IL-1F6 Protein, Human (153a.a)

    IL-36 alpha; IL-36α; Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6

    		Human E. coli
    IL-36 alpha (IL-1F6), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 alpha mediates inflammatory response. IL-36 alpha binds to IL-36R and activates NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 alpha also binds to IL-1Rrp2 and recruit IL-1RAcP. IL-36 alpha activats the MAPK, Erk1/2 and JNK through IL-36R/IL-1RAcP. IL-36 alpha/IL-1F6 Protein, Human (153a.a) is a recombinant human IL-36 alpha (K6-F158) without any tag, which is produced in E. coli.
  • HY-P700126AF
    Animal-Free IL-36 alpha/IL-1F6 Protein, Human (His)

    IL-36 alpha; IL-36α; Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6

    		Human E. coli
    IL-36 α/IL-1F6 protein binds to IL1RL2/IL-36R receptor, activates NF-kappa-B and MAPK pathways, and induces pro-inflammatory responses. IL-36 α/IL-1F6 also upregulates CD83, CD86, and HLA-DR in dendritic cells, promotes dendritic cell maturation, and drives T cell proliferation. Animal-Free IL-36 alpha/IL-1F6 Protein, Human (His) is the recombinant human-derived animal-FreeIL-36 alpha/IL-1F6 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-36 alpha/IL-1F6 Protein, Human (His) is 153 a.a., with molecular weight of ~18.05 kDa.
  • HY-P700210AF
    Animal-Free IL-36 alpha/IL-1F6 Protein, Mouse (His)

    Il36a; Fil1e; Il1e; Il1f6; Il1h1Interleukin-36 alpha; FIL1 epsilon; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 6; IL-1F6; Interleukin-1 homolog 1; IL-1H1

    		Mouse E. coli
    IL-36 alpha protein binds to the IL1RL2/IL-36R receptor and activates the NF-kappa-B and MAPK signaling pathways. Animal-Free IL-36 alpha/IL-1F6 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-36 alpha/IL-1F6 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-36 alpha/IL-1F6 Protein, Mouse (His) is 160 a.a., with molecular weight of ~18.82 kDa.
  • HY-P72547
    IL-36 alpha/IL-1F6 Protein, Mouse (153a.a)

    Interleukin-36 alpha; IL-36A; IL-1 epsilon; IL-1F6; IL-1H1

    		Mouse E. coli
    IL-36 alpha (IL-1F6), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 alpha mediates inflammatory response. IL-36 alpha binds to IL-36R and activates NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 alpha also binds to IL-1Rrp2 and recruit IL-1RAcP. IL-36 alpha activats the MAPK, Erk1/2 and JNK through IL-36R/IL-1RAcP. IL-36 alpha/IL-1F6 Protein, Mouse (153a.a) is a recombinant mouse IL-36 alpha (R8-H160) without any tag, which is produced in E. coli.
  • HY-P72544
    IL-36 gamma/IL-1F9 Protein, Mouse

    Interleukin-36 gamma; IL-36γ; IL36G; IL-1F9; IL-1H1

    		Mouse E. coli
    IL-36 gamma (IL-1F9), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 gamma mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 gamma/IL-1F9 Protein, Mouse is a recombinant mouse IL-36 gamma (G13-S164) without any tag, which is produced in E. coli.
  • HY-P72546
    IL-36 beta/IL-1F8 Protein, Mouse (153a.a)

    Interleukin-36 beta; FIL1 eta; IL-1 eta; IL-1F8; IL-1H2; IL36B

    		Mouse E. coli
    IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 beta/IL-1F8 Protein, Mouse (153a.a) is a recombinant mouse IL-36 beta (S31-K183) without any tag, which is produced in E. coli.
  • HY-P700211AF
    Animal-Free IL-36 gamma/IL-1F9 Protein, Mouse (His)

    Interleukin-36 gamma; IL-36γ; IL36G; IL-1F9; IL-1H1

    		Mouse E. coli
    IL-36 gamma/IL-1F9 protein activates NF-κB through IL1RL2 and promotes local inflammatory responses in the epithelial barrier. It affects keratinocytes, dendritic cells and T cells, promoting tissue infiltration, cell maturation and proliferation. Animal-Free IL-36 gamma/IL-1F9 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-36 gamma/IL-1F9 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-36 gamma/IL-1F9 Protein, Mouse (His) is 152 a.a., with molecular weight of ~18.27 kDa.
  • HY-P74803AF
    Animal-Free IL-36 beta/IL-1F8 Protein, Human (His)

    Il36b; Fil1e; Il1f8; Interleukin-36 beta; Interleukin-1 family member 8; IL-1F8

    		Human E. coli
    IL-36 beta/IL-1F8 Protein, signaling through IL-36R, activates NF-kappa-B and MAPK pathways, inducing a pro-inflammatory response. Present in epithelial barriers, it shares the IL-1 system coreceptor IL1RAP. Stimulates IL-6, IL-8, antimicrobial peptides, and matrix metalloproteases. Involved in skin inflammation, influencing keratinocytes, dendritic cells, and T-cells. Induces chemokines and cytokines, promoting tissue infiltration and cell maturation. Interacts with TMED10 for translocation from cytoplasm to ERGIC for secretion. Animal-Free IL-36 beta/IL-1F8 Protein, Human (His) is the recombinant human-derived animal-FreeIL-36 beta/IL-1F8 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-36 beta/IL-1F8 Protein, Human (His) is 153 a.a., with molecular weight of ~18.17 kDa.
  • HY-P75861AF
    Animal-Free IL-36 gamma/IL-1F9 Protein, Human (His)

    IL-36 gamma; IL-36γ; Interleukin-36 gamma; IL36G; IL-1-related protein 2; IL-1RP2; IL-1 epsilon; IL-1F9; Interleukin-1 homolog 1; IL-1H1

    		Human E. coli
    IL-36 gamma/IL-1F9 protein activates the NF-kappa-B and MAPK pathways, induces the expression of various chemokines and pro-inflammatory factors, and promotes local inflammatory responses in the epithelial barrier. It affects keratinocytes, dendritic cells, and T cells, driving tissue infiltration, maturation, and proliferation. Animal-Free IL-36 gamma/IL-1F9 Protein, Human (His) is the recombinant human-derived animal-FreeIL-36 gamma/IL-1F9 protein, expressed by E. coli , with C-His, C-His labeled tag. The total length of Animal-Free IL-36 gamma/IL-1F9 Protein, Human (His) is 152 a.a., with molecular weight of ~17.98 kDa.
  • HY-P72545
    IL-36 beta/IL-1F8 Protein, Human (157a.a)

    Interleukin-36 beta; FIL1 eta; IL-1 eta; IL-1F8; IL-1H2; IL36B

    		Human E. coli
    IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 beta/IL-1F8 Protein, Human (157a.a) is a recombinant human IL-36 beta (M1-E157) without any tag, which is produced in E. coli.
  • HY-P74803
    IL-36 beta/IL-1F8 Protein, Human (His)

    Il36b; Fil1e; Il1f8; Interleukin-36 beta; Interleukin-1 family member 8; IL-1F8

    		Human E. coli
    IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 beta/IL-1F8 Protein, Human (His) is a recombinant human IL-36 beta (K5-E157) with N terminal His tag, which is produced in E. coli.
  • HY-P75861
    IL-36 gamma/IL-1F9 Protein, Human (152a.a, His)

    Interleukin-36 gamma; IL-36γ; IL36G; IL-1F9; IL-1H1

    		Human E. coli
    IL-36 gamma (IL-1F9), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 gamma mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 gamma/IL-1F9 Protein, Human (152a.a, His) is a recombinant human IL-36 gamma (S18-D169) with His tag, which is produced in E. coli.
Cat. No. Product Name Effect Purity