HVEM
null Herpesvirus entry mediator (HVEM, TNFRSF14, CD270) is a TNF receptor superfamily member with an unusually broad interactome that positions it as a molecular switch between co-stimulation and inhibition. HVEM binds four TNF-family ligands-LIGHT, LTα1β2, CD160 ligand activity and BTLA's counterpart-as well as the Ig superfamily members BTLA and CD160, which deliver inhibitory signals when engaged by HVEM. Expressed on T cells, B cells, NK cells, dendritic cells and epithelial cells, HVEM transduces TRAF2/5-dependent NF-κB and PI3K-AKT survival signals via its ligand LIGHT, promoting T-cell activation, memory generation and mucosal immunity; conversely, HVEM acting as a ligand for BTLA and CD160 dampens T-cell and NK-cell responses, enforcing peripheral tolerance and intestinal homeostasis. Herpes simplex virus glycoprotein D exploits HVEM for viral entry. Dysregulated HVEM signaling contributes to autoimmunity, inflammatory bowel disease and tumor immune escape, and HVEM loss in tumors correlates with T-cell exclusion.
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HVEM 組換えタンパク質 (9)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
