2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-17
  6. IL-25/IL-17E

IL-25/IL-17E

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Interleukin-25 (IL-25), also known as IL-17E, belongs to the IL-17 cytokine family. IL-25 shares only 16% homology with IL-17A and has biological effects that largely differ from those of the other members of the family. IL-25 is originally found in Th2 cells. IL-25 is also produced by various immune cells such as CD8+ T cells, mast cells, macrophages, dendritic cells (DCs), eosinophils, basophils, group 2 innate lymphoid cells (ILC2s), epithelial and endothelial cells. IL-25 binds to IL-17RB and then binds to IL-17RA to exert its activity. IL-25 induces the expression of IL-4, IL-5, IL-13, TGF-β, and G-CSF. IL-25 can stimulate cell proliferation, inhibition of apoptosis, production of inflammatory cytokines and chemokines, modulation of cell-cell adhesion, and cell motility in nonimmune cells. IL-25 activates NF-κB, MAPKs and JAK/STAT signaling pathways[1]. Human and mouse IL-25 shares 78.88% sequence identity. Mouse and rat IL-25 shares 91.12% sequence identity.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72555
    IL-25/IL-17E Protein, Human (HEK293, His)

    Interleukin-25; IL-25; Interleukin-17E; IL-17E

    		Human HEK293
    IL-25/IL-17E cytokines are produced by eosinophils, Th2 cells, and epithelial cells and critically regulate the adaptive immune response by modulating cytokine production. It enhances local and systemic type 2 helper T cell responses through its IL17RA and IL17RB receptors and activates the JAK2-STAT5A pathway. IL-25/IL-17E Protein, Human (HEK293, His) is the recombinant human-derived IL-25/IL-17E protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-25/IL-17E Protein, Human (HEK293, His) is 145 a.a., with molecular weight of 20-26 kDa.
  • HY-P700116AF
    Animal-Free IL-25/IL-17E Protein, Human (His)

    Interleukin-25; IL-25; Interleukin-17E; IL-17E

    		Human E. coli
    IL-25/IL-17E cytokines are produced by eosinophils, Th2 cells, and epithelial cells and critically regulate the adaptive immune response by modulating cytokine production. It enhances local and systemic type 2 helper T cell responses through its IL17RA and IL17RB receptors and activates the JAK2-STAT5A pathway. Animal-Free IL-25/IL-17E Protein, Human (His) is the recombinant human-derived animal-FreeIL-25/IL-17E protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-25/IL-17E Protein, Human (His) is 145 a.a., with molecular weight of ~17.68 kDa.
  • HY-P73198
    IL-25/IL-17E Protein, Mouse (His)

    Interleukin-25; IL-25; Interleukin-17E; IL-17E

    		Mouse HEK293
    Interleukin-25 (IL-25), also known as IL-17E, belongs to the IL-17 cytokine family. IL-25 activates NF-κB, MAPKs and JAK/STAT signaling pathways. IL-25 exerts singal transduction through receptors composed of IL17RA and IL17RB. IL-25/IL-17E Protein, Mouse (His) is the recombinant mouse-derived IL-25/IL-17E protein, expressed by HEK293 , with N-His labeled tag. The total length of IL-25/IL-17E Protein, Mouse (His) is 153 a.a., with molecular weight of 30-35 kDa.
  • HY-P74812
    IL-25/IL-17E Protein, Rat (HEK293, Fc)

    Interleukin-25; IL-25; Interleukin-17E; IL-17E

    		Rat HEK293
    IL-25/IL-17E is a member of the IL-17 family. IL-25/IL-17E Protein, Rat (HEK293, Fc) is the recombinant rat-derived IL-25/IL-17E protein, expressed by HEK293 , with N-hFc labeled tag. The total length of IL-25/IL-17E Protein, Rat (HEK293, Fc) is 153 a.a., with molecular weight of ~50 kDa.
  • HY-P75858
    IL-25/IL-17E Protein, Canine (HEK293, Fc)

    Interleukin-25; IL-25; Interleukin-17E; IL-17E

    		Canine HEK293
    Interleukin 25, also known as IL-17E, is a unique cytokine of the IL-17 family. Interleukin 25 exclusively was shown to strongly induce expression of the cytokines associated with type 2 immunity. Interleukin 25 is a “barrier surface” cytokine whose expression depends on extrinsic environmental factors and when up-regulated may lead to inflammatory disorders such as atopic dermatitis, psoriasis or asthma. IL-25/IL-17E Protein, Canine (HEK293, Fc) is the recombinant canine-derived IL-25/IL-17E protein, expressed by HEK293 , with N-hFc labeled tag. The total length of IL-25/IL-17E Protein, Canine (HEK293, Fc) is 153 a.a., with molecular weight of ~46.2 kDa.
  • HY-P700201AF
    Animal-Free IL-25/IL-17E Protein, Mouse (His)

    Interleukin-25; IL-25; Interleukin-17E; IL-17E

    		Mouse E. coli
    Interleukin-25 (IL-25), also known as IL-17E, belongs to the IL-17 cytokine family. IL-25 activates NF-κB, MAPKs and JAK/STAT signaling pathways. IL-25 exerts singal transduction through receptors composed of IL17RA and IL17RB. Animal-Free IL-25/IL-17E Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-25/IL-17E protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-25/IL-17E Protein, Mouse (His) is 153 a.a., with molecular weight of ~18.41 kDa.
  • HY-P74813
    IL-25/IL-17E Protein, Human (HEK293, Fc)

    Interleukin-25; IL-25; Interleukin-17E; IL-17E

    		Human HEK293
    IL-25/IL-17E cytokines are produced by eosinophils, Th2 cells, and epithelial cells and critically regulate the adaptive immune response by modulating cytokine production. It enhances local and systemic type 2 helper T cell responses through its IL17RA and IL17RB receptors and activates the JAK2-STAT5A pathway. IL-25/IL-17E Protein, Human (HEK293, Fc) is the recombinant human-derived IL-25/IL-17E protein, expressed by HEK293 , with N-hFc labeled tag. The total length of IL-25/IL-17E Protein, Human (HEK293, Fc) is 175 a.a., with molecular weight of 50-60 kDa.
  • HY-P701012
    IL-25/IL-17E Protein, Human (Biotinylated, HEK293, His-Avi)

    IL-25; IL-17E; IL17E; Interleukin-17E; interleukin-25

    		Human HEK293
    IL-25/IL-17E cytokine, produced by eosinophils, Th2 cells, and epithelial cells, crucially regulates adaptive immune responses by modulating cytokine production. It enhances T-helper type 2 responses locally and systemically through its IL17RA and IL17RB receptor, activating the JAK2-STAT5A pathway. This activation leads to the secretion of type-2-associated cytokines, including IL4, IL9, and IL13, while inhibiting Th17 cell differentiation. IL-25 also induces IL8 and IL6 release from eosinophils via MAPK and NF-kappa-B pathways, emphasizing its regulatory role in immune responses. IL-25/IL-17E Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-25/IL-17E protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IL-25/IL-17E Protein, Human (Biotinylated, HEK293, His-Avi) is 145 a.a., with molecular weight of 25-35 kDa.
Cat. No. Product Name Effect Purity