CD51/Integrin alpha V
CD51, the integrin alpha V chain, dimerizes with beta subunits (beta 1, beta 3, beta 5, beta 6 or beta 8) to form receptors for RGD motif-containing matrix proteins including vitronectin, fibronectin, osteopontin and latent TGF-beta. Expressed on endothelial cells, osteoclasts, fibroblasts, platelets and subsets of leukocytes, alpha V integrins govern angiogenesis, bone resorption, wound repair and phagocytosis of apoptotic cells. The alpha V beta 6 and alpha V beta 8 receptors activate latent transforming growth factor beta, linking matrix contact to fibrosis and immune regulation. Integrin alpha V antagonists have been pursued as anti-angiogenic therapeutics in oncology.
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CD51/Integrin alpha V Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
