2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Phosphatase
  5. Serine/Threonine Phosphatase

Serine/Threonine Phosphatase

Recombinant Protein Expression Service

Serine/Threonine Phosphatase

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7705
    Calcineurin B Protein, Human (His)

    rHuCNB, His; Calcineurin Subunit B Type 1; PPP3R1; CNB

    		Human E. coli
    Calcineurin B Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Calcineurin Subunit B Type 1 is an anti-tumor factor.
  • HY-P76759
    Calcineurin A/PPP3CA Protein, Human (sf9, His)

    Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; CALNA; CNA

    		Human Sf9 insect cells
    Calcineurin A, also known as PPP3CA, is a calcium-dependent, calmodulin-stimulated protein phosphatase that plays a pivotal role in transducing intracellular Ca(2+)-mediated signals. Known substrates often contain a PxIxIT motif and/or an LxVP motif, highlighting the specificity of its phosphatase activity. In response to elevated Ca(2+) levels, Calcineurin A dephosphorylates and activates phosphatase SSH1, leading to cofilin dephosphorylation. Furthermore, upon increased Ca(2+) levels following mitochondrial depolarization, Calcineurin A dephosphorylates DNM1L, inducing its translocation to the mitochondrion. The protein also positively regulates CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. Calcineurin A dephosphorylates and activates transcription factor NFATC1, thereby regulating NFAT-mediated transcription by promoting nuclear translocation. Its broad array of functions includes the dephosphorylation of heat shock protein HSPB1, transcription factor ELK1, DARPP32, CRTC2, TFEB, and KLHL3, suggesting a crucial role in various cellular processes such as kidney development, secretion of salivary enzymes, bone formation, immune responses, and regulation of ion transport. The multifaceted roles of Calcineurin A underscore its significance in diverse cellular functions and signal transduction pathways. Calcineurin A/PPP3CA Protein, Human (sf9, His) is the recombinant human-derived Calcineurin A/PPP3CA protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Calcineurin A/PPP3CA Protein, Human (sf9, His) is 520 a.a., with molecular weight of ~60 kDa.
  • HY-P76438
    ILKAP/PP2C delta Protein, Human (HEK293, His)

    Integrin-linked kinase-associated serine/threonine phosphatase 2C; ILKAP; PP2C delta

    		Human HEK293
    The ILKAP/PP2C delta protein is a key phosphatase that potentially regulates cell cycle progression by dephosphorylating substrates essential for proliferation. It selectively binds to ILK and regulates cell adhesion and growth factor signaling. ILKAP/PP2C delta Protein, Human (HEK293, His) is the recombinant human-derived ILKAP/PP2C delta protein, expressed by HEK293 , with C-His labeled tag. The total length of ILKAP/PP2C delta Protein, Human (HEK293, His) is 392 a.a., with molecular weight of ~46 KDa.
Cat. No. Product Name Effect Purity