ILKAP/PP2C delta
ILKAP (integrin-linked kinase-associated phosphatase), also designated PP2C delta, is a member of the PP2C family of Mn2+/Mg2+-dependent serine/threonine phosphatases. Unlike the calcineurin subunits grouped with it here, ILKAP acts without calcium or calmodulin and functions as a monomer with a single PP2C catalytic domain. It binds integrin-linked kinase and dephosphorylates ILK on its activation-loop serine, thereby restraining ILK-dependent signaling, and it has also been reported to inhibit NF-kappaB activity and to suppress cell growth and promote apoptosis in cultured cells. ILKAP is broadly expressed across tissues. Recombinant ILKAP is used in PP2C activity assays and studies of integrin signaling crosstalk.
-
ILKAP/PP2C delta Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
