ILKAP/PP2C delta Protein, Human (HEK293, His)

The ILKAP/PP2C delta protein is a key phosphatase that potentially regulates cell cycle progression by dephosphorylating substrates essential for proliferation. It selectively binds to ILK and regulates cell adhesion and growth factor signaling. ILKAP/PP2C delta Protein, Human (HEK293, His) is the recombinant human-derived ILKAP/PP2C delta protein, expressed by HEK293 , with C-His labeled tag. The total length of ILKAP/PP2C delta Protein, Human (HEK293, His) is 392 a.a., with molecular weight of ~46 KDa.

ILKAP/PP2C delta protein emerges as a key phosphatase with potential implications in the regulation of cell cycle progression by dephosphorylating substrates crucial for cell proliferation. This protein selectively associates with integrin-linked kinase (ILK), exerting modulatory effects on cell adhesion and growth factor signaling. ILKAP/PP2C delta specifically inhibits the ILK-GSK3B signaling axis, suggesting a role in restraining the pathway's activity. Such inhibition may play a critical role in impeding oncogenic transformation, emphasizing ILKAP/PP2C delta's significance as a potential tumor suppressor. The intricate interplay between ILKAP/PP2C delta, ILK, and downstream signaling pathways underscores its regulatory role in fundamental cellular processes, with implications for both cell cycle dynamics and oncogenic transformation control.

Human

HEK293

C-His

Q9H0C8 (M1-H392)

80895  [NCBI]

Approximately 46 kDa.

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.