2. Disease Areas
  3. Metabolic or Endocrine Disease
  4. Hypothalamic-Pituitary-Adrenal Regulation

Hypothalamic-Pituitary-Adrenal Regulation

Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, characterized by impaired negative feedback and elevated cortisol levels due to chronic stress, is strongly associated with the pathophysiology of affective disorders such as depression and anxiety.

 

Hypothalamic-Pituitary-Adrenal Regulation (4):

Cat. No. Nombre del producto No. CAS Pureza Estructura química
  • HY-101366
    A-61603 107756-30-9 99.34%
    A-61603 is a selective α1A/α1a-adrenergic receptor agonist with Ki of 8.89 nM for rat submaxillary gland α1A, Ki of 30.5 nM for cloned bovine α1a. A-61603 potentiates Ca2+ transients with EC50 of 6.9 nM. A-61603 stimulates phosphoinositide hydrolysis, induces contractile responses in vas deferens, prostate strips, and spleen strips, and exhibits low activity in aortic rings. A-61603 can be used for research on adrenergic function.
    A-61603
  • HY-B0237
    Aminoglutethimide 125-84-8 98.87%
    Aminoglutethimide (DL-Aminoglutethimide) is an orally active anticonvulsant with various endocrine-related side effects. Aminoglutethimide blocks multiple steroid hormone synthesis pathways by inhibiting several cytochrome P-450-dependent hydroxylases, such as aromatase, cholesterol side-chain cleavage enzyme, 11-hydroxylase, and 18-hydroxylase, with IC50 values of 0.3, 3.5, 120, and 20 μM, respectively. Aminoglutethimide reduces cortisol levels. Aminoglutethimide can be used in research on Cushing's syndrome, breast cancer, and other conditions.
    Aminoglutethimide
  • HY-P10964
    Tezusomant 2802416-72-2
    Tezusomant is a growth hormone receptor antagonist. Tezusomant is promising for research on diseases caused by excessive growth hormone secretion, such as acromegaly.
    Tezusomant
  • HY-129040
    m-Iodobenzylguanidine 80663-95-2
    m-Iodobenzylguanidine (Iobenguane) is a ligand with high affinity against norepinephrine transporter (NET). m-Iodobenzylguanidine is used as an imaging agent in the diagnostic imaging and radionuclide studies of neuroendocrine tumors, such as neuroblastoma, pheochromocytoma and carcinoid tumor.
    m-Iodobenzylguanidine